散发性急性病毒性肝炎血清学分型的研究  

Studies on Serotyping of Sporadic Acute Viral Hepatitis

作　　者：王玉才 韩文清 安运国 孙颖 宫连风 

机构地区：[1]山东省烟台市卫生防疫站

出　　处：《中华预防医学杂志》1997年第3期147-148,共2页Chinese Journal of Preventive Medicine

摘　　要：为研究非甲型肝炎流行季节散发性急性病毒性肝炎的病原学构成，采用ＥＩＡ法，对２４８份急性病毒性肝炎患者血清，进行了血清学分型检测。结果显示，非甲型肝炎流行期散发病例仍以甲型肝炎为主，占６１．３％，以青少年为主，随年龄增长患病率降低。乙型肝炎居第二位占２６．２％，以中老年为主，随年龄增长患病率增高。丙型肝炎占９．９％，戊型肝炎占２２．２％，各年龄组间变化不明显。丁型肝炎患病率为１２．７％，ＨＤＡｇ检出率为１２％。双重感染占１８．９％，检测指标全部阴性占０．８％。丙型和戊型肝炎的ＩｇＧ型抗体与同期献血员比较，差异有非常显著性。病例中黄疸型占６８％，甲型肝炎占黄疸总数的８６．８％。乙型肝炎患者合并或联合感染丁型肝炎，病情易慢性化。Two hundred and forty eight blood specimens collected from patients of sporadic acute viral hepatitis were serotyped with enzyme immunoassay (EIA), to study its pathogenic components during non epidemic seasons of hepatitis A (HA). Results showed that HA accounted for 61.3% of the total sporadic acute hepatitis cases during its non epidemic seasons, occurred mainly in youngsters and decreased with increase of their age. Hepatitis B (HB) ranked the second and accounted for 26.2%, occurred mainly in the middle aged and the elderly and its prevalence increased with age. Hepatitis C (HC) accounted for 9.9% and hepatitis E (HE) 22.2% of the total cases, without obvious age difference. Prevalence of hepatitis D (HD) was 12.7%, with a positive rate of hepatitis D antigen (HDAg) of 12%. Superinfection accounted for 18.9%, and the viral hepatitis markers were all negative in 0.8% of the total cases. There was very significant difference in prevalence of HCV IgG and HEV IgG between sporadic acute hepatitis patients and blood donors during the same periods. Icterus occurred in 68% of the total cases, 86.8% in HA. Patients of HB complicated with HD were liable to chronicity.

关 键 词：病毒性肝炎 血清分型 

分 类 号：R512.602[医药卫生—内科学]