溴氰菊酯对大鼠大脑皮层突触膜谷氨酸受体结合的影响  

Effects of Deltamethrin on the Binding of Glutamate Receptor to Rat Cerebral Cortical Synaptosomal Membrane

作　　者：赵西龙[1,2] 朱晓峰[1,2] 石年[1,2] 刘毓谷[1,2] 

机构地区：[1]中国预防医学科学院环境卫生监测所 [2]同济医科大学环境医学研究所

出　　处：《中华预防医学杂志》1997年第3期157-159,共3页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金

摘　　要：为研究溴氰菊酯对大鼠大脑皮层突触膜谷氨酸受体结合功能的影响，应用放射配基受体结合法进行了观察。结果显示，在１×１０－８～１×１０－４ｍｏｌ／Ｌ剂量下，溴氰菊酯明显增加突触膜与３Ｈ－谷氨酸的结合量，而且具有剂量效应关系。与二甲基亚砜溶剂对照比较，谷氨酸结合率增加３．２％～１３．５％。受体－配基结合动力学分析呈现正协同作用，表明溴氰菊酯神经兴奋毒作用可能与中枢谷氨酸递质系统紊乱有关。Effects of deltamethrin on the binding function of glutamate receptor of cerebral cortical synaptosomal membrane in rat were studied by radio labeled ligand receptor binding assay. Results showed that deltamethrin could obviously increase the 3H glutamate binding to synaptosomal membrane, by doses of 1×10 -8 to 1×10 -4 mol/L, with a dose dependent relationship. Glutamate binding rate increased by 3.2 percent to 13.5 percent in deltamethrin treated group, as compared with dimethyl sulfoxide solvent controls. Binding dynamic analysis of receptor and ligand showed that an obvious synergistic action of deltamethrin and dimethyl sulfoxide. It indicated that neurotoxicity of deltamethrin could be related to the disturbance of central transmitter system of glutamate.

关 键 词：除虫菊酯 谷氨酸 神经毒性 大脑皮层 突触膜 

分 类 号：R992[医药卫生—毒理学]