铝对小鼠宫内胚胎发育致畸作用的研究  

Studies on Teratogenic Effects of Aluminum on Intra Uterine Fetal Development in Mice

作　　者：林邦和[1,2,3] 张人韬[1,2,3] 朱舜丽[1,2,3] 金至清[1,2,3] 

机构地区：[1]安徽中医学院组织学与胚胎学教研室 [2]上海大学化学化工系 [3]安徽中医学院中医药研究所生化室

出　　处：《中华预防医学杂志》1997年第3期166-168,共3页Chinese Journal of Preventive Medicine

摘　　要：为了了解铝的胚胎毒性，用实验畸胎学的方法，研究了孕期里经口摄入不同剂量铝对妊娠小鼠宫内胚胎发育的影响。结果发现，铝的过量摄入对小鼠胚胎发育具有明显的致畸作用和毒性。它可导致胚胎发生露脑畸形和骨发育不全，及胎儿宫内生长迟缓和小鼠胚胎死亡率升高，并表现出明显的剂量－效应关系。提示，铝的过量摄入可能是先天性神经管缺陷（ＮＴＤｓ）和胎儿宫内生长迟缓（ＩＵＧＲ）以及围产儿死亡的危险因素之一。Effects of oral administration of different doses of aluminum during pregnancy on intra uterine fetal development in mice were studied with experimental teratological methods. Results showed that over intake of aluminum could lead obvious teratogenic and toxic effects on fetal development in mice. It could cause formation of encephalocele and dysostosis, intra uterine fetal growth retardation, and increase of embryo death rate, with a obvious dose dependent relation. It suggests that excessive ingestion of aluminum may be one of the risk factors contributing to congenital neural tube defects, intra uterine fetal growth retardation and perinatal deaths.

关 键 词：铝 致畸作用 胚胎发育异常 

分 类 号：R714.431[医药卫生—妇产科学] R995[医药卫生—临床医学]