广东地区婴肝患儿的HCV感染  

HCV infection in patients with infantile hepatitis syndrome

作　　者：鄢璞[1] 苏燕莉[1] 陈光华[1] 张美德[1] 陈峥嵘[1] 曾荣新[1] 郑秀霞[1] 唐振亚[2] 郝连杰[2] 

机构地区：[1]广州市儿童医院,510120 [2]同济医科大学附属同济医院临床免疫研究室

出　　处：《实用儿科临床杂志》1997年第2期77-79,共3页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨广东地区婴儿肝炎综合征中丙型肝炎病毒感染及其传播途径。方法采用酶联免疫吸附法（ELISA法）检测血清中丙型肝炎病毒（HCV）抗体，多聚酶链反应（PCR）检测血清中HCVRNA。结果90例婴肝中有11例HCV标志阳性，阳性率为12．2％（11／90），其中抗HCV以及HCVRNA均阳性4例，单项抗HCV阳性3例，单项HCVRNA阳性4例。母亲抗HCV阳性2例。结论HCV感染是广东地区婴儿肝炎综合征中一个不可忽视的病因，本组11例阳性患者的传播途径主要与输注血制品有关，其次为母婴传播。Objectives To investigate for HCV infection and its route of transmission in patients with infantile hepatitis syndrome in Guangdong area.Methods Anti-HCV and HCV RNA in serum were detected by ELISA and PCR respectively.Results Eleven out of 90 infants with hepatitis were positive for HCV marks. The positive rate Was 12. 2 % (11/90). Among of them 4 cases had simultaneously anti-HCV and HCV RNA. The other positive patients included 3 cases with antiHCV and 4 cases with HCV RAN.Conclusions The results indicated that HCV infection is an important factor in infantile hepatitis syndrome in Guangdong area. The route of transmission in the HCV positive patients was mainly related to using blood and its products. The second was mother to infant transmission.

关 键 词：婴儿 肝炎综合征 丙型肝炎病毒 广东 

分 类 号：R725.126[医药卫生—儿科]