甲磺酸地拉韦啶解离常数及分配系数的测定  

Determination of the dissociation constant and partition coefficient of mesylate delavirdine

作　　者：管清香[1] 林天慕[2] 王恩思[1] 

机构地区：[1]吉林大学药学院,吉林长春130021 [2]吉林大学生命科学学院,吉林长春130013

出　　处：《药学实践杂志》2007年第5期290-291,共2页Journal of Pharmaceutical Practice

基　　金：吉林省卫生厅重点实验室项目(项目编号:2005055)

摘　　要：目的:测定甲磺酸地拉韦啶的解离常数和分配系数。方法:采用酸碱滴定法测定不同体积比的甲醇-水溶液中的药物pKa值,再外推至纯水中药物浓度无限稀释时的pKa值。采用HPLC法测定药物的分配系数。结果:甲磺酸地拉韦啶的pKa为4.635,1gP值为2.907。结论:甲磺酸地拉韦啶为弱酸性亲脂性药物。Objective ： To determine the dissociation constant and partition coefficient of mesylate delavirdine. Methods ：The dissociation constant was determined with acid-base titration method in methanol/water solutions with different ratios, the value to infinite diluted in pure water was extrapolated and the partition coefficient was determined with bottle-shaking method by HPLC. Results： The pKa and 1 gP of mesylate delavirdine in n-octyl alcohol were 4.635 and 2. 907 respectively. Conclusions ： mesylate delavirdine is a weak acid with lipophilic property.

关 键 词：甲磺酸地拉韦啶 解离常数 分配系数 酸碱滴定法 

分 类 号：R942[医药卫生—药剂学]