诺氟沙星金属盐的合成及体外抑菌实验  

Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro

作　　者：贺全山[1] 杨昌云[2] 陈维中[1] 杨湘越[1] 戎姜凯[3] 

机构地区：[1]南京军区福州总医院药学科,福建福州350025 [2]中国人民解放军第180医院药械科,福建泉州362000 [3]第二军医大学药学院,实习生上海200433

出　　处：《药学实践杂志》2007年第5期303-306,共4页Journal of Pharmaceutical Practice

摘　　要：目的:制备诺氟沙星金属盐类新化学单体及观察其体外抑菌活性。方法:以诺氟沙星及数种金属盐为原料进行化学合成,以固体培养基平板药敏试验方法对合成品作体外抑菌试验观察其活性。结果:完成诺氟沙星银、诺氟沙星锌、诺氟沙星铈、诺氟沙星钴、诺氟沙星铋5种金属盐的合成及其初步质量标准考察。结论:体外抑菌实验表明,诺氟沙星银、诺氟沙星锌、诺氟沙星铈、诺氟沙星钴、诺氟沙星铋对金黄色葡萄球菌、大肠杆菌、绿脓假单胞菌的抑制作用明显高于磺胺嘧啶银。Objective：To synthesize metallic salts of norfloxacin （NFLO） and evaluate their bacteriaostatic activities in vitro. Methods： The compounds were syntherized from the starting material norfloxacin and metallic salts. The bateriostatic activities of these new compounds were tested. Results： Five new compounds （NFLO-Ag,, NFLO-Zn, NFLO-Ce, NFLO-Co, NFLO-Bi） were produced and their primary quality criteria were established. Conclusions： The bateriostatie tests showed that these new compounds exhibit more potent antimicrobial activities than sliver sulfadiazine against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa.

关 键 词：诺氟沙星银 诺氟沙星锌 诺氟沙星铈 诺氟沙星钴 诺氟沙星铋 合成 体外抑菌 

分 类 号：R978.19[医药卫生—药品]