注射用盐酸头孢替安与果糖注射液的配伍稳定性考察  

Compatible Stability of Cefotiam Hydrochloride for Injection with Fructose Injection

作　　者：周蕾[1] 苗佩宏[1] 胡忠杰[1] 

机构地区：[1]武警浙江省总队医院,嘉兴市314000

出　　处：《中国药房》2007年第29期2279-2280,共2页China Pharmacy

摘　　要：目的:考察注射用盐酸头孢替安与果糖注射液的配伍稳定性。方法:采用紫外分光光度法,测定配伍液在25℃条件下放置8h内不同时间点的含量变化,并观察其外观及测定pH值和微粒粒径。结果:6h内配伍液澄明,色泽无变化,pH值和头孢替安的含量均无明显变化,微粒符合2005年版《中国药典》规定。结论:注射用盐酸头孢替安与果糖注射液配伍6h内稳定。OBJECTIVE： To investigate the compatible stability of cefotiam hydroloride for injection with fructose injection. METHODS： The content changes of the mixture within 8h at 25℃ were determined by UV spectrophotometry, and its external appearance was observed, and the pH value as well as particle size of the mixture were measured.RESULTS： The mixture was clear within 6h, showing no visible changes in appearance, pH value and contents of cefotiam, with particles in line with the standard stated in China Pharmacopeia （2005 edition ） .CONCLUSION： The mixture of ceforiam hydrochloride for injection and fructose injection is stable within 6h.

关 键 词：紫外分光光度法 盐酸头孢替安 果糖 稳定性 

分 类 号：R927.11[医药卫生—药学]