Scanning for signatures of geographically restricted selection based on population genomics analysis  

作　　者：DENG LiBin TANG XiaoLi KANG Jian WANG QingYun ZENG ChangQing 

机构地区：[1]Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101300, China [2]Graduate University of Chinese Academy of Sciences, Beijing 100049, China [3]Department of Mathematical Sciences, School of Science, Tsinghua University, Beijing 100084, China [4]School of Mathematical Sciences, Beijing Normal University, Beijing 100875, China

出　　处：《Chinese Science Bulletin》2007年第19期2649-2656,共8页

摘　　要：Natural selection, as the driving force of human evolution, has direct impact on population differentiation. However, it is still unclear to what extent the genetic differentiation has been caused by natural selection. To explore this question, we performed a genome-wide scan with single nucleotide polymorphism (SNP) data from the International HapMap Project. Single locus FST analysis was applied to assess the frequency difference among populations in autosomes. Based on the empirical distribution of FST, we identified 12669 SNPs correlating to population differentiation and 1853 candidate genes subjected to geographic restricted natural selection. Further interpretation of gene ontogeny revealed 121 categories of biological process with the enrichments of candidate genes. Our results suggest that natural selection may play an important role in human population differentiation. In addition, our analysis provides new clues as well as research methods for our understanding of population differentiation and natural selection.Natural selection, as the driving force of human evolution, has direct impact on population differentiation. However, it is still unclear to what extent the genetic differentiation has been caused by natural selection. To explore this question, we performed a genome-wide scan with single nucleotide polymorphism （SNP） data from the International HapMap Project. Single locus FsTanalysis was applied to assess the frequency difference among populations in autosomes. Based on the empirical distribution of FsT, we identified 12669 SNPs correlating to population differentiation and 1853 candidate genes subjected to geographic restricted natural selection. Further interpretation of gene ontogeny revealed 121 categories of biological process with the enrichments of candidate genes. Our results suggest that natural selection may play an important role in human population differentiation. In addition, our analysis provides new clues as well as research methods for our understanding of population differentiation and natural selection.

关 键 词：单核苷酸 基因多态性 染色体 扫描技术 

分 类 号：Q78[生物学—分子生物学]