PHBV微球/磷酸钙骨水泥复合材料研究  

Properties of the Calcium Phosphate Cement/PHBV Microspheres Composites

作　　者：刘海兰[1] 董利民[1] 王晨[1] 昝青峰[1] 田杰谟[1] 

机构地区：[1]新型陶瓷与精细工艺国家重点实验室清华大学核研院精细陶瓷研究室,北京100084

出　　处：《稀有金属材料与工程》2007年第A02期40-42,共3页Rare Metal Materials and Engineering

基　　金："973"项目(2005CB623905);北京市教育委员会共建项目建设计划资助;国家自然科学基金项目(30330570)

摘　　要：采用在磷酸钙骨水泥中添加一定量的PHBV微球来制备在初期有较高的抗压强度,而后随着PHBV微球的降解,在磷酸钙骨水泥基体中形成三维孔隙结构的PHBV微球/磷酸钙骨水泥复合材料。选用的骨水泥的固相成分以α-TCP为主,液相成分为NaH_2PO_4/Na_2HPO_4、KH_2PO_4/K_2HPO_4缓冲溶液,PHBV微球直径为100μm～300μm,主要研究不同的固化液,固液比以及PHBV微球添加量对PHBV/磷酸钙骨水泥复合材料抗压强度等性能的影响,制备出凝固时间在15min～30min,具备一定可注射性,抗压强度达到10MPa～30 MPa的PHBV微球/磷酸钙骨水泥复合材料。最终制备的PHBV微球/磷酸钙骨水泥复合材料能够满足骨修复材料的要求。A new calcium phosphate cement composites were developed by adding PHBV microspheres, which had higher compressive strength in the early days and had three-dimensional pore structure in the later days due to degradation of PHBV microspheres. In the cement, the solid component was α-TCP, the liquid component was NaH2PO4/Na2HPO4 solution or KH2PO4/K2HPO4 solution, and the diameter of PHBV microspheres is about 100μm-300μm. The effect of the liquid component, the ratio of the solid component and the liquid component and the proportion of PHBV microspheres on the setting time and the compressive strength were studied. The final setting times were15 minutes-30 minutes, and the compressive strengths were 10 MPa-30 MPa. The properties of the composites indicated that the materials could be used as bone repair materials.

关 键 词：骨水泥 PHBV微球 复合材料 

分 类 号：R318.08[医药卫生—生物医学工程]