壳聚糖交联特性对壳聚糖/β-TCP微球成球性的影响  

Effect of Chitosan Cross-linking Properties on Spherical Formation of Chitosan/β-TCP Microspheres

作　　者：昝青峰[1] 成鹏[1] 李兆新[1] 王晨[1] 董利民[1] 田杰谟[1] 

机构地区：[1]清华大学新型陶瓷与精细工艺国家重点实验室,清华大学核能与新能源技术研究院精细陶瓷室,北京100084

出　　处：《稀有金属材料与工程》2007年第A02期54-57,共4页Rare Metal Materials and Engineering

基　　金："973"项目(2005CB623905);北京市教育委员会共建项目建设计划;国家自然科学基金项目(30330570);清华大学新型陶瓷与精细工艺国家重点实验室开放课题资助

摘　　要：采用反相乳液悬浮法制备壳聚糖/β-TCP复合微球,在乳化前通过向壳聚糖/β-TCP溶液中加入戊二醛溶液的方法引入初交联工艺,目的在于提高复合微球的交联强度。通过动态流变学方法研究发现,加入交联剂后,壳聚糖溶液的粘度随搅拌时间的延长而增加,最后形成凝胶。根据所需微球的形貌及球径要求选择适当粘度的壳聚糖/β-TCP溶液作为水相进行乳化.结合所制备微球的形貌特点发现,在加入3m10.5%(质量分数,下同)的戊二醛溶液,初交联时间为10min时,制得的微球形貌最佳,其球径在100～450μm范围内且分布均匀。Chitosan/β-TCP composite microspheres were fabricated by solid-in-water-in-oil （s/w/o） emulsion cross-linking method. In order to improve the cross-linking strength of the microspheres, the preparatory cross-linking procedure was introduced by adding dilute glutaraldehyde solution into chitosan/β-TCP slurry before emulsion in liquid paraffin. By rheological measuring, the kinetics of the initial stage of gelation in chitosan/β-TCP slurry containing glutaraldehyde was studied. When the procedure parameters of preparatory cross-linking were 3ml, 0.5%wt, and 10min, the optimal microspheres, which possess good spherical shape, and about 100μm -450μm of diameter, could be obtained.

关 键 词：壳聚糖 Β-TCP 微球 交联 成球性 

分 类 号：R318.08[医药卫生—生物医学工程]