磷酸钙基组织工程化多孔微球的制备工艺研究  

Fabrication of Calcium Phosphate-Based Tissue-Engineering Porous Microspheres

作　　者：成鹏[1] 王晨[1] 昝青峰[1] 董利民[1] 田杰谟[1] 

机构地区：[1]清华大学核能与新能源技术研究院精细陶瓷室,北京100084

出　　处：《稀有金属材料与工程》2007年第A02期65-67,共3页Rare Metal Materials and Engineering

基　　金："973"项目(2005CB623905);国家自然科学基金项目(30330570);清华大学骨干人才支持计划;清华大学新型陶瓷与精细工艺国家重点实验室开放课题资助

摘　　要：以β-磷酸三钙(β-TCP)和壳聚糖(CS)为主要原料,采用反相乳液悬浮法制备出β-TCP/CS复合微球,并经1150℃条件下烧结,得到主要成分为β-TCP的无机微球。X射线衍射分析得到经烧结后微球相成分主要为β-TCP,扫描电镜观察微球形貌表明微球成球性好、表面粗糙,激光粒度分析仪测定微球粒径主要分布在150～450μm。生物实验表明微球具有良好的生物活性。The β-TCP/CS composite microspheres were prepared by a solid-in-water-in-oil （s/w/o） emulsion cross-linking method, which were sintered at 1150℃to obtain β-TCP microspheres. XRD results showed that the crystal phase of the sintered microspheres was β-TCP. The surface morphology and microstructure were evaluated by SEM, and the size distributions were mainly distributed in 150μm-450μm. And the porosity, bulk density and apparent density of β-TCP microspheres were measured by mercury porosimeter. Cells cultured experiments presented the good biocompatibility of β-TCP microspheres. The results indicate that the β-TCP-based microspheres are potential materials as tissue engineering scaffolds for bone repair.

关 键 词：Β-磷酸三钙 微球 骨组织工程 

分 类 号：R318.08[医药卫生—生物医学工程]