一种新型复相Ca-P支架材料的制备及生物学行为  

Preparation and Biological Evaluation of A Novel Diphase Ca-P Scaffold Material

作　　者：黄炎[1] 鲜苏琴[1] 王诗美[1] 王婷婷[1] 廖运茂[1] 

机构地区：[1]四川大学口腔生物医学工程教育部重点实验室,四川成都610041

出　　处：《稀有金属材料与工程》2007年第A02期75-78,共4页Rare Metal Materials and Engineering

基　　金：四川省科技重点项目(04GG009-023-02)资助

摘　　要：采用溶胶-凝胶法制备纯羟基磷灰石支架,并在其表面构造双相钙磷陶瓷膜层。并用SEM,FTIR,XRD对其进行表征,结果表明该法制得的材料为孔隙彼此贯通的多孔结构,孔径约为300～600μm,涂膜厚度约为20～50μm,孔壁上分布大量纳米级微孔。与对照材料HA相比,成骨细胞在4天后可以更多的粘附到该材料表面增殖分化(P<0.05):体内埋植实验表明,经12周该材料具有更早的成骨效应和更多的成骨量(P<0.05)新型复相Ca-P支架材料有利于骨组织修复。To explore a novel diphase Ca-P scaffold material which had good bioactivity and long-term osteogenesis, a pure HA scaffold coated with diphase calcium phosphate ceramics film was prepared by sol-gel method. The material was studied by SEM, FTIR, XRD respectively and results indicated that it possessed through porous structure, whose diameter was between 300 -600 μm; the film was 20 -50 μm in thickness. The results of cranii osteoblast culture showed that the cells could adhere to and grow into material surface, showing better functional activity than HA culture medium after 4 days（P〈0.05）. The results of implantation in the rabbits showed that after 12 weeks more new bone formed compared with the HA group（P〈0.05）. The novel diphase Ca-P scaffold material was advantageous to restoration of the bone defect.

关 键 词：钙磷陶瓷 溶胶-凝胶法 支架 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]