绝经后妇女血维生素B12、叶酸水平与骨密度相关性的初步研究  

Relation of serum vitamin B12 and serum folate to bone mineral density in postmenopansal women

作　　者：游利[1] 盛正妍[1] 张黎铭[2] 陈瑾瑜[1] 

机构地区：[1]上海交通大学附属第一人民医院骨质疏松科,200080 [2]上海交通大学附属第一人民医院核医学科,200080

出　　处：《中国骨质疏松杂志》2007年第1期26-28,共3页Chinese Journal of Osteoporosis

摘　　要：目的 探讨绝经后妇女血维生素B12、叶酸水平与骨密度的相关性.方法 应用双能X线骨密度仪测定受试者腰椎及股骨骨密度,按1994年WHO标准将其分为3组,即骨质疏松组、骨量减少组及骨量正常组;采取空腹静脉血进行维生素B12、叶酸的集中检测;并分别进行维生素B12、叶酸与不同部位骨密度的相关性分析.结果 ①骨质疏松组的血维生素B12的水平（512.55±209.85）pg/ml,低于骨量减少组（551.29±237.71）pg/ml和骨量正常组（565.71±189.03）pg/ml.②骨质疏松组的血叶酸的水平（11.27±6.04）pg/ml,低于骨量减少组（13.18±6.14）pg/ml和骨量正常组（11.9±3.73）pg/ml.③绝经后妇女血维生素B12的水平与全髋BMD呈正相关（r=0.25,p＜0.01）,与股骨颈BMD呈正相关（r=0.212,P＜0.05）,与股骨干BMD呈正相关（r=0.257,P＜0.01）,与股骨大转子BMD呈正相关（r=0.239,P＜0.05）;血维生素B12的水平与L1～L4 BMD无相关性（r=0.141,P＞0.05）.④绝经后妇女血叶酸的水平与全髋BMD、股骨颈BMD、股骨干BMD、股骨大转子BMD和L1～L4 BMD均无相关（r分别为0.005,0.021,0.017,-0.021和0.078,P＞0.05）.结论 绝经后妇女血维生素B12的水平的缺乏可能是骨质疏松发生的一个重要风险因素,叶酸的缺乏并非骨质疏松发生的风险因素.Objective To study whether in postmenopansal women levels of serum vitamin B12 and serum folate are related to bone mineral density（BMD）. Methods （1） Serum vitamin 12 levels and serum folate levels were measured using chemiluminescence （DPC corporation ）. （2）BGP and FFH levels were measured by chemiluminescence （equipment is Roche E170）. （3）ALP, Ca and P were measured by automated biochemistry techniques. （4）BMD was measured using dual energy X-ray analysis（GE PRODIGY Inc. ） at the lumbar spine（L1- L4 ） and at the left hip（total hip,trochanter, Ward＇s area and femoral neck）. Results （ 1 ） Osteoporotic women had lower values of serum vitamin B12 [ osteoporosis group （512.55 ± 209.85 ） pg/ml, osteopenia group （551.29 ± 237.71 ） pg/ml and normal group （565.71 ± 189.03） pg/ml] . （2） Osteoporotic women had lower values of serum folate [osteoporosis group （11.27±6.04） pg/ml than osteopenia group （13.18±6.14） pg/ml and normal group （11.9±3.73） pg/ml]. （3） Low vitamin B12 level and low BMD xalue at each of the hip sites and for total hip are of positive correlation（total hip r = 0.25, P 〈 0.01, trochamer r = 0.239, P 〈 0.05, shaft of femur r = 0.257, P 〈 0.01 and femoral neck r = 0.212, P 〈 0.05）. Low vitamin B12 level and low BMD value at lumbar spine（ L1-L4 ） are of no correlation（ r = 0. 141, P 〉 0.05）. Low folate levels and low BMD value at each of the hip sites and for total hip are of no correlation（total hip r = 0.005, P 〉 0.05,trochanter r = - 0.021, P 〉 0.05, shaft of femur r = 0.017, P 〉 0.05 and femoral neck r = 0.021, P 〉 0.05）. Low folate levels and low BMD value at lumbar spine（ L1-L4 ） are of no correlation（ r = 0.078, P 〉 0.05）. Conclusions Serum vitamin B12 deficiency may be an important risk factor for osteoporosis. Serum folate deficiency isn＇t a risk factor for osteoporosis.

关 键 词：维生素B12 骨密度 绝经后 

分 类 号：R681[医药卫生—骨科学]