ESBLs大肠埃希菌Ⅰ类整合子与耐药性关系  

Relationship between Class 1 Integron and Resistance in Clinical ESBLs-producing Escherichia Coli Strain

作　　者：王寰[1] 范晓磊[2] 

机构地区：[1]大连医科大学附属第二医院北院,辽宁大连116031 [2]大连医科大学微生物教研室,辽宁大连116027

出　　处：《医学与哲学（B）》2007年第9期55-56,共2页Medicine & Philosophy(B)

摘　　要：整合子通过位点特异的基因重组在临床细菌耐药性传播中起重要作用。根据整合酶基因intI的序列不同将整合子划分成4种类型,其中第一类整合子最常见,决定着细菌的多重耐药。产ESBLs菌株在整合子水平转移的介导下能增加捕获这些基因盒的可能性,更有利于耐药基因的传递和扩散。Integrons are dements that participate in a powerful site - specific recombination system and play a major role in spreading antibiotic resistance genes in a clinical setting. Four class of integrons have been identified according to their respective integrons found in clinical isolates and are strongly associated with multipleantibiotic resistance. Moreover, Extended spectrum β- lactamases（ESBls）genes can be located on integrons, which may facilitate the spread of such genetic dements.

关 键 词：整合子 大肠埃希菌 多重耐药性 

分 类 号：R446.1[医药卫生—诊断学]