子痫妇女胎盘瘦素与神经肽Y水平测定及其意义  

Clinical significance of lepton and NPY in placento of patients with eclampsia.

作　　者：周立岩[1] 王志红[1] 李美杰[1] 

机构地区：[1]山东省青岛市第八人民医院妇产科,266100

出　　处：《中国妇幼保健》2007年第28期3998-4001,共4页Maternal and Child Health Care of China

摘　　要：目的:检测子痫各期妇女胎盘瘦素与神经肽Y的水平,观察二者之间的关系及探讨在子痫发病中的作用。方法:用免疫组化法检测49例子痫各期妇女(其中轻度子痫前期17例,重度子痫前期18例,子痫14例)及40例正常妊娠妇女胎盘瘦素与神经肽Y的水平,观察二者之间及与血压的相关关系。结果:①子痫妇女组胎盘瘦素水平明显高于正常妊娠妇女组,差异有高度显著性(P<0.01),而子痫妇女组中子痫期妇女胎盘瘦素水平又显著高于轻、重度子痫前期妇女组,差异有显著性(P<0.05)。②子痫妇女组胎盘神经肽Y水平明显高于正常妊娠妇女组,差异有高度显著性(P<0.01),而子痫妇女组中子痫期妇女胎盘神经肽Y水平又显著高于轻、重度子痫前期妇女组,差异有高度显著性(P<0.01)。③子痫妇女组胎盘瘦素水平与胎盘神经肽Y水平呈高度正相关性(r=0.753,P<0.01)。④子痫妇女组胎盘瘦素水平与收缩压、舒张压、平均动脉压呈正相关,相关系数分别为0.313、0.412、0.402,P均<0.05。结论:胎盘瘦素与神经肽Y水平在子痫妇女组明显升高,胎盘瘦素与神经肽Y水平升高可能是子痫发病的重要机制。Objective： To investigate the placento leptin and NPY in patients with eclampsia and normal pregnancies and to study its clinical significance. Methods： SABC （Strept Avidin - Biotin Complex） was used to measure the levels of leptin and NPY in 49 patients with eclampsia （17 mild pre- eclampsia, 18 severe pre- eclampsia and 14 eclampsia） and 40 normal pregnant women. Placento-leptin levels were correlated with NPY and BP. Results： （1）Placento levels of leptin in eclampsia were higher than those in normal pregnant women （ P 〈 0. 01 ） and there was great difference between eclampsia and pre - eclampsia （ P 〈 0. 05 ） . （2）The levels of plaeento NPY in PIH group were higher than that in normal pregnant women （P 〈0.01 ） and there was great difference between moderate severe and mild PIH （P 〈0. 01 ） . （3）Placento leptin levels correlated with NPY ccncentrations （r = 0. 753, P 〈 0. 01 ） . （4）The placento levels of leptin positively correlated with the levels of SBP, DBP and MAP （ r = 0. 313, 0. 412, 0. 402, P 〈 0.05 ） respectively. Conclusion ： The levels of leptin and NPY in placento increase in patients with eclampsia, which might play an important role in pathogenesisof eclampsia. Elevated placento leptin and NPY 1 evels may be the key mechanism of eclampsia.

关 键 词：子痫 高血压 胎盘 瘦素 神经肽Y 

分 类 号：R714[医药卫生—妇产科学]