血脂异常患者血清载脂蛋白水平的相关性分析  

An analysis of relativity on serum apolipoprotein in patients with dyslipidemia

作　　者：胡雷光[1] 陈坚[1] 朱立岳[1] 王昕蕾[1] 

机构地区：[1]上海市静安区中心医院检验科,上海200040

出　　处：《检验医学》2007年第5期548-550,共3页Laboratory Medicine

摘　　要：目的探讨血清载脂蛋白(apo)水平对血脂异常患者中罹患各种疾病的诊断价值。方法检测206例高三酰甘油(TG>1.7 mmol/L)血症患者血清apo A-Ⅰ、apo B、apo CⅡ和apo CⅢ水平的变化,并以101名健康者作为对照组,观察高TG血症患者罹患各种疾病的apo血清水平的相互关系。结果冠心病组、糖尿病组、脑梗死组、其他疾病组与正常对照组比较,除apo A-I降低外,apo B、apo CⅡ和apo CⅢ均升高(P<0.01)。在高TG血症患者中,冠心病组、糖尿病和脑梗死组与其他疾病组比较,分别表现为apo CⅡ和apo CⅢ,apo B、apo CⅡ和apo CⅢ,apo B和apo CⅢ血清水平不同程度的升高(P<0.05、P<0.01)。结论有高TG血症的冠心病、糖尿病和脑梗死患者存在着apo的代谢紊乱,而不同组合的apo B、apo CⅡ和apo CⅢ血清水平的升高分别与这些疾病的发病危险因素有一定的相互关系。Objective To explore the value of serum apolipoprotein（apo） level in diagnosing various diseases for patients with dyslipidemia. Methods The serum levels of apo A-Ⅰ,apo B,apo CⅡ and apo CⅢ in 206 high level triglyceride（TG〉1.7 mmol/L） patients were determined and their changes were observed.The results were compared with those of 101 healthy people（as a control group） . Results In coronary heart disease（CHD）,diabetes mellitus（DM）,cerebral infarction（CI） and other diseases,apo B,apo CⅡand apo CⅢ were all higher than those in the control group except apo A-Ⅰ （P〈0.01）. Among high level TG groups patients,the levels of apo CⅡ and apo CⅢ in CHD,the levels of apo B,apo CⅡ and apo CⅢ in DM,the levels of apo B and apo CⅢ in CI were higher than those in the groups of patients with other diseases（P〈0.05,P〈0.01）. Conclusions The hyper-triglyceridemia patients with CHD,DM and CI have metabolism disorder of apo.The main incidence risk factors of those diseases are considerably related to the change of apo B,apo CⅡ and apo CⅢ levels.

关 键 词：载脂蛋白 血脂异常 三酰甘油 

分 类 号：Q513[生物学—生物化学]