2’-脱氧腺苷全合成研究  

Synthesis Research of 2'-deoxyadenosine

作　　者：蒋忠良[1] 李乾坤[1] 齐湘兵[1] 杨晓章 

机构地区：[1]同济大学化学系,上海200092 [2]浙江天台药业有限公司,浙江天台317200

出　　处：《同济大学学报（自然科学版）》2007年第9期1264-1268,共5页Journal of Tongji University:Natural Science

基　　金：国家自然科学基金资助项目(29971023)

摘　　要：从简单的化合物葡萄糖和嘌呤开始,利用全合成的方法,通过十步反应合成了脱氧腺苷,总收率达到7.04%.其中通过五步反应从D-葡萄糖合成了重要的中间体脱氧核糖,对其实验过程进行了创新,使收率从文献的17.1%提高到29.8%,并优化了实验条件,更宜于推广应用.产物经过红外(IR),核磁氢谱(1H NMR),质谱(MS)验证.2＇-deoxyadenosine is synthesized by whole synthesis from the simplest compound-glucose. The total yield is promoted to 7.04%, and our research is also focused on the syntheses of 2- deoxyribose. Old ways are improved and some trials on new synthesis process are conducted creatively, with the yield improved from 17.1% to 29.8%. The product was verified by IR, 1H NMR and MS.

关 键 词：脱氧腺苷 脱氧核糖 葡萄糖 全合成 

分 类 号：O629[理学—有机化学]