两种组胺受体拮抗剂对内毒素作用下雏鸡体温的影响  

The Effect of Lipopolysaccharide (LPS) Challenged by Two Histamine Receptor Antagonists on Body Temperature of Chicken

作　　者：付学智[1] 欧德渊[1] 许乐仁[1] 李进国[1] 谭建民[1] 

机构地区：[1]贵州大学动物科学学院,贵州贵阳550025

出　　处：《贵州农业科学》2007年第5期79-81,共3页Guizhou Agricultural Sciences

基　　金：贵州省优秀人才基金项目"组胺在肺动脉高压综合症中的作用机理研究"[黔省专合字2005(349)]

摘　　要：为了研究组胺H1、H2受体拮抗剂对内毒素攻毒后雏鸡体温的影响,探讨内源性组胺在内毒素攻毒时导致雏鸡发热的作用机理。采用100羽雏鸡随机分5组,即模型组、扑尔敏组、西咪替丁组、扑和西联合组和空白组。空白组中午腹腔注射生理盐水,其余各组注射等剂量的LPS,早、晚肌注相应药物。实验持续15 d,分别于攻毒后0 d、5 d、10 d、15 d,各组随机抽10个样本。在注射LPS后0 h、2 h、4 h6、h,测定雏鸡直肠温度,结果:(1)急性实验中,扑尔敏组2 h、4 h体温显著降低(P<0.05);而西咪替丁组和扑和西联合组在2h时体温极显著降低(P<0.01)。(2)慢性实验中,0 d5、d体温无显著差异;10 d、15 d扑尔敏组体温显著降低(P<0.05);15 d扑尔敏组、扑和西联合组体温显著降低(P<0.05)。结果表明:在内毒素引起的炎症反应中,内源性组胺主要是通过H1受体介导体温升高。Two histamine receptor antagonists were tested to investigate its effect of lipopolysaccharide（LPS） on body temperature of chicken and the fever mechanism by the endogenous histamine. The results showed that in the acute test the body temperature of the chicken group injected by chlorpheniramine significantly dropped （P〈 0. 05） at 2h and 4h after injection and the body temperature of the chicken group injected by chlorpheniramine and cimetidine very significantly dropped （P〈0. 01） at 2h after injection compared with CK, that in the chronic test there was no significant difference at 0d and 4d in the body temperature, the body temperature of the chicken group injected by chlorpheniramine significantly dropped （P〈0.05） at 10d and 15d after injection and the body temperature of the chicken group injected by chlorpheniramine and cimetidine significantly dropped （P〈0. 05） at 15d after injection. The conclusion is that the endogenesis histamine raises the body temperature mainly by H1 acceptor in the inflammation induced by LPS.

关 键 词：组胺 内毒素 组胺受体拮抗剂 雏鸡 体温 

分 类 号：S858.31[农业科学—临床兽医学]