补肾壮骨冲剂治疗310例骨质疏松症患者5年观察  

Five-year observation on the effects of Bushen Zhuanggu granules on 310 osteoporosis patients

作　　者：邓伟民[1] 邵玉[1] 张金玉[1] 马建青[1] 崔伟历[1] 韦蒿[1] 贺扬淑[1] 

机构地区：[1]广州军区广州总医院康复科,广州510010

出　　处：《中国骨质疏松杂志》2007年第10期736-738,共3页Chinese Journal of Osteoporosis

基　　金：广东省科技计划项目(2005B40301005);广东省中医药管理局科研课题(97318)

摘　　要：目的观察5年补肾壮骨冲剂治疗老年性骨质疏松症的疗效,以期了解中医药治疗老年性骨质疏松症远期效果。方法于1997-07～2004-07选择2家医院门诊的老年性骨质疏松症患者310例为研究对象,其中治疗组174例,空白对照组136例,治疗组口服补肾壮骨冲剂,空白对照组只接受对症治疗。采用丹麦产1100A单光子骨密度仪,测量非优势左前臂尺、桡骨。计算出前臂骨矿含量和骨密度。结果①治疗6个月后两组骨矿含量和骨密度结果比较:治疗组骨矿含量、骨密度均明显高于治疗前(P<0.01),空白对照组骨矿含量、骨密度均低于入组时(P<0.01),组间比较差异具有显著性(P<0.01);②骨折发生率:治疗组低于空白对照组,差异有显著性意义(P<0.01)。结论补肾壮骨冲剂长期服用能明显提高及稳定老年性骨质疏松症患者骨矿含量、骨密度水平,降低新骨折率。Objective To observe the effects of Busben Zhuanggu granules（BZG） in osteoporosis patients for five years and investigate the long-term effect of traditional Chinese medicine on osteoporosis. Methods Totally 310 elderly outpatients from 2 hospitals with osteoporosis from July 1997 to July 2004, were divided into treatment group （n = 174,treated with Bushen Zhuanggu granules） and blank control group （n = 136, only received symptomatic treatment）. Non-domimant left forearm ulna and radius were measured with the 1100A photon bone densitiometry, and the bone mineral content （BMC） and bone mineral density （BMD） were calculated. Results ① The comparison of BMC and BMD in the two groups after 6 months： the BMC and BMD were obviously higher than that before treatment in the treatment group（ P 〈 0.01 ）, and markedly lower than that before treatment in the blank control group（ P 〈 0.01 ） ; The difference between the two groups was significant （ P 〈 0.01 ） ; ② Fracture rate： The rate of treatment group was lower than that of blank control group （ P 〈 0.01 ）. Conclusion Long-term medication of Bushen Zhuanggu granules can effectively increase and stabilize the BMC and BMD and decrease the fracture rate of eldly patients with osteoporosis.

关 键 词：骨质疏松/中药疗法 骨矿含量 骨密度 骨折 

分 类 号：R681[医药卫生—骨科学]