药物所致重症多形红斑和中毒性表皮坏死松解症的临床研究  

Clinical study of Stevens Johnson syndrome and toxic epidermal necrolysis induced by drug

作　　者：马成林[1,2] 郭哲[1,2] 韩秀萍[1,2] 屈年贺[1,2] 

机构地区：[1]中国医科大学第二医院皮肤科 [2]中国医科大学校部

出　　处：《临床皮肤科杂志》1997年第2期95-96,共2页Journal of Clinical Dermatology

摘　　要：对药物所致重症多形红斑（ＳＪＳ）和中毒性表皮坏死松解症（ＴＥＮ）进行了对比研究。两者最常见的致敏药物是解热镇痛药，其次是抗生素类和镇静抗癫痫药。ＳＪＳ和ＴＥＮ的发病年龄、性别和潜伏期无差异，但ＴＥＮ的发热时间、急性期和恢复期时间明显长于ＳＪＳ，发热程度、粘膜损害程度和合并症发生率明显高于ＳＪＳ。ＳＪＳ预后良好，无１例死亡。ＴＥＮ的死亡率高达３９％。关于皮质类固醇激素在治疗ＴＥＮ中的应用，我们认为早期短程应用是必要的，同时注意液体与电解质的补充，营养供应和皮肤粘膜的护理。A comparative study of Stevens Johnson syndrome(SJS) and toxic epidermal necrolysis(TEN) induced by drug was carried out. The drug most commonly involved was analgesics, followed by the antibiotics and sedative anticonvulsants. There were no difference between SJS and TEN on the age, sex and period of incubation, but the time of fever, acute and recovery phase of TEN were longer than SJS, the degree of fever, mucous membrane involvement and the incidence of complication were higher in TEN than in SJS. The prognosis for SJS was good and there was no death. The mortality for TEN was higher (39%). In the treatment of TEN, we think it is necessary to use corticosteroids at early stage for a short duration, supply fluid and electrolytes and nutrients and give adequate nursing care of skin and mucous membrane.

关 键 词：多形红斑 表皮坏死松解症 SJS TEN 药源性疾病 

分 类 号：R758.61[医药卫生—皮肤病学与性病学] R758.59[医药卫生—临床医学]