我国部分地区HCV感染者抗-HCV抑制率的研究  

A PRELIMINARY STUDY OF ANTIBODY RESPONSE TO HCV IN HCV CARRIERS FROM SOME AREAS IN CHINA

作　　者：宋宏彬[1,2] 王海涛[1,2] 唐时幸[1,2] 吉保新 张习坦 

机构地区：[1]军事医学科学院微生物流行病研究所 [2]新疆军区后勤部卫生防疫队

出　　处：《解放军预防医学杂志》1997年第3期171-174,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：国家自然科学基金

摘　　要：收集了我国部分地区ＨＣＶ感染者血清３６３份，分别做了抗－ＨＣＶＥＬＩＳＡ和抗－ＨＣＶ中和抑制试验。结果显示，我国不同地区（甚至同一地区不同民族）ＨＣＶ感染者抗－ＨＣＶ抑制率不同，而且中和抑制试验前后平均ＯＤ值的差异也有所不同，特别是西藏地区藏族和新疆地区维吾尔族分别只有３．２％和３０．８％抗－ＨＣＶ（＋）血清能被同种多肽抗原所抑制，提示我国不同地区人群（甚至同一地区不同民族）ＨＣＶ感染者的抗－ＨＣＶ免疫反应性不同，并可能与不同地区的ＨＣＶ变异性有关。Three hundred and sixty-three serum samples of HCV carriers were collected from some areas in China. The ELISA and neutralization inhibition test were performed. The results showed that the neutralization inhibition rates, and the average OD values of pre- and post-neutralization inhibition were significantly different among the human sera from the different areas and the different nationalities in the same area, especially in those sera from Tibet and Xinjiang, only 3.2% and 30.8% sera with anti-HCV(+) were inhibited by the same peptides respectively. This was probably related with HCV heterogenicity,

关 键 词：丙型肝炎病毒 ELISA 中和抑制试验 

分 类 号：R512.630.3[医药卫生—内科学]