氢化可的松的合成研究进展  

Research advances of hydrocortisone synthesis

作　　者：贾春燕[1] 陈建新[1] 尹秋响[1] 王静康[1] 

机构地区：[1]天津大学化工学院,天津300072

出　　处：《中国抗生素杂志》2007年第9期525-530,共6页Chinese Journal of Antibiotics

基　　金：国家自然科学基金(20676092);中国博士后科学基金(2005038466)

摘　　要：氢化可的松是哺乳动物主要的肾上腺皮质激素类药物和重要的甾体药物合成的中间体。本文简要综述了其全化学合成、半合成法及全生物合成方法、路径的国内、外现状及相关进展情况,并对其发展方向进行了评述和展望。Hydrocortisone is the major glucocorticoid and an important intermediate in steroid drug synthesis. The main synthetic approaches and progresses including total chemical synthesis, semi-synthesis and whole-cell hioconversion for hydrocortisone manufacture in domestic and other countries were briefly reviewed. Prospective and evaluation of hydrocortisone synthesis were also discussed.

关 键 词：氢化可的松 甾体药物 化学合成 半合成法 生物合成 

分 类 号：TQ467[化学工程—制药化工]