肾动态显像法与双血浆法在移植肾GFR测定中的对比  

Comparison of glomerular filtration rates derived from dynamic renal imaging and dual sample clearance in kidney transplantation

作　　者：朱阳军[1] 杜晓英[2] 李林法[1] 张军[1] 

机构地区：[1]浙江大学医学院附属第一医院核医学科,杭州310003 [2]浙江大学医学院附属第一医院肾内科,杭州310003

出　　处：《中华核医学杂志》2007年第4期243-244,共2页Chinese Journal of Nuclear Medicine

摘　　要：目的比较肾动态显像法与双血浆法测定的移植肾^(99)Tc^m-DTPA 肾小球滤过率(dGFR和 tGFR),以评价 dGFR 反映移植肾滤过功能的可靠性。方法选取73例肾移植患者,分别采用肾动态显像法和双血浆法测定其^(99)Tc^m-DTPA GFR。分析经体表面积标准化的 dGFR 与 tGFR 间的关系,并建立直线回归方程。结果 dGFR 均值略低于 tGFR 均值(t=-2.010,P<0.05),dGFR 与 tGFR 呈显著正相关(r=0.759,P<0.01),直线回归方程:tGFR=0.6455×dGFR+25.514。结论 dGFR 与 tGFR 具有较好的一致性,肾动态显像法能够准确评价移植肾的滤过功能。Objective Glomerular filtration rate （GFR） is one of the valuable indictors of allograft status after kidney transplantation. The feasibility of an easy measurement of GFR by dynamic renal imaging （dGFR） was assessed in comparison to a classical dual plasma sample method （tGFR） in the current study for evaluating the function of grafting kidney. Methods In 73 patients of kidney transplantation, both dynamic renal imaging and dual sample GFR measurement were undertaken after ^99Tc^m-DTPA injection. The correlation between dGFR and tGFR, both being standardized according to surface area, was analyzed and the linear regression equation was obtained. Results The mean dGFR was slightly lower than that of tGFR （t = -2. 010, P 〈 0.05 ）. The dGFR correlated significantly with tGFR （r = 0. 759, P 〈 0. 01 ）. The linear regression equation was tGFR = 0. 6455 x dGFR ＋ 25.514. Conclusion The dGFR correlated well with tGFR and they were accurate in evaluating the filtration function of transplanted kidney.

关 键 词：肾移植 肾小球滤过率 放射性核素显像 

分 类 号：R699.2[医药卫生—泌尿科学] R817.4[医药卫生—外科学]