^(153)Sm-citrate-HA滑膜切除术治疗类风湿关节炎患者57例近期疗效分析  

Evaluation on ^(153)Sm-citrate-hydroxyapatite synovectomy in 57 patients with rheumatoid arthritis

作　　者：梅坚[1] 王强[2] 寿涛[1] 杨吉生[2] 李芹[1] 和芳[1] 张虹[1] 沈达炜[2] 

机构地区：[1]云南省第一人民医院风湿免疫科,昆明650032 [2]云南省第一人民医院核医学科,昆明650032

出　　处：《中华核医学杂志》2007年第4期248-249,共2页Chinese Journal of Nuclear Medicine

摘　　要：目的观察^(153)Sm-柠檬酸-羟基磷灰石(citrate-HA)滑膜切除术治疗类风湿关节炎(RA)所致膝关节滑膜增生的近期疗效。方法对57例 RA 患者103个有明显滑膜增生的膝关节行关节腔内注射^(153)Sm-citrate-HA 5×37 MBq(0.5～1 ml),比较治疗前后关节症状(疼痛、肿胀、积液、功能活动度、上下楼及蹲站受限)变化情况,按优效、良效、微效、无效4级标准评判疗效,并对不同 X 线分期患者的疗效进行分析。结果治疗后1周开始起效,在半年内疗效逐渐明显,患者关节症状逐渐减轻甚至消失;总有效率为98.1%,其中Ⅰ、Ⅱ期患者的优效率分别为100%和91.3%。结论^(153)Sm-citrate-HA 滑膜切除术对 RA 滑膜增生性变是一项简单、安全、有效的治疗方法。Objective Radiation synovectomy with ^153 Sm-citrate-hydroxyapatite （HA） was reported of promising effect. The aim of the current study was to investigate the efficacy of the technique in treating rheumatoidarthritis （RA）. Methods Fifty-seven RA patients （103 knees） with thickened synovium underwent the treatment with intra-articular injection of 185 MBq （0.5 - 1 ml） ^153Sm-citrate-HA. Based on the changes of clinical signs such as articular pain, edema, etc. after treatment, the therapeutic efficacy was graded along with X-ray grading. Results Efficacy was observed 1 week after injection and persisted up to 6 months. The overall efficiency was 98.1%. There were 100% and 91.3% patients in X-ray grade Ⅰ and Ⅱ responding to the treatment respectively. Conclusion Radiation synovectomy with intra-articular injection of ^153 Sm-citrate-HA in patients with RA could be a simple, safe and effective therapy

关 键 词：关节炎 类风湿 近距离放射疗法 治疗结果 钐 羟基磷灰石类 柠檬酸盐类 

分 类 号：R817.5[医药卫生—影像医学与核医学]