灯盏花素对实验性2型糖尿病大鼠周围神经病变防治作用的研究  

Effect of Breviscapine on peripheral neuropathy in rats with type 2 diabetes mellitus

作　　者：刘立新[1] 吴秀品[1] 陈立峰[1] 刘好文[2] 

机构地区：[1]石家庄市第三医院神经内科,050011 [2]河北医科大学第三医院神经内科

出　　处：《疑难病杂志》2007年第10期605-607,F0003,共4页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的观察灯盏花素对2型糖尿病大鼠周围神经病变的防治作用。方法将Wistar大鼠随机分为对照组(10只)、模型组,对照组正常规饮食,模型组用高糖高脂饮食加小剂量链脲佐菌素(STZ)注射诱导2型糖尿病,然后把成模大鼠分为2组:糖尿病组、治疗组各14只。治疗组给予灯盏花素10mg.kg-1.d-1。分别于用药后1、3个月测定血脂、血糖,坐骨神经运动传导速度,并观察腓肠神经病理改变。结果治疗组大鼠血脂、血糖较糖尿病组明显降低,坐骨神经运动传导速度较糖尿病组明显提高(P<0.05或P<0.01),腓肠神经有髓神经纤维数量和纤维总截面积增加,较糖尿病组亦明显加大(P<0.05P<0.01)。结论灯盏花素对实验性2型糖尿病大鼠周围神经损害有一定防治作用。Objective To study the effect of Breviscapine on peripheral neuropathy in type 2 diabetes melli- tus rats. Methods The rat models of type 2 diabetes mellitus were induced by feeding high-sugar and high-fat diet, with low-dose streptozotocin （STZ） intraperitoneal injection （30 mg/kg）, Then the model rats were divided into two groups： diabetes mellitus group, treatment group （the rats were fed with Breviscapine 10mg·kg^-1·d^-1）. After 1,3 month of administration, the plasma glucose, plasma fat, electrophysioloyic changes and the pathological development of sutal nerve were observed. Results In treatment group, plasma g[ucose and plasma fat were significantly lower than those of diabetes mellitus group,however,the motor conduction velocity of sciatic nerve was significantly increased, as compared with that of diabetes mellitus group （ P 〈 0.05 or P 〈 0.01）.The pathological changes in treatment group was lighter than those of diabetes mellitus group （ P 〈 0.05 or P 〈 0.01）. Conclusion Breviscapine has certain preventive and therapeutic effect on peripheral netu＇opathy in rats with type 2 diabetes mellitus.

关 键 词：灯盏花素 糖尿病 2型 周围神经病 糖尿病 大鼠 

分 类 号：R285.5[医药卫生—中药学]