尿N-乙酰-β-D-氨基葡萄糖苷酶对汞作业者肾脏损害的早期诊断意义  

SIGNIFICANCE OF DETERMINATION OF N-ACETYL-Β-D-GLUCOSAMINIDASE FOR EARLY DIAGNOSIS OF RENAL DAMAGE IN MERCURY WORKERS

作　　者：赵立强[1] 陈俊华[2] 伏代刚[1] 顾华强[1] 游全程[1] 李晓莉[1] 

机构地区：[1]四川大学华西第四医院,成都610041 [2]四川省疾病预防控制中心

出　　处：《现代预防医学》2007年第19期3612-3613,共2页Modern Preventive Medicine

基　　金：四川大学临床新技术基金资助课题(NO.0083504126006)

摘　　要：[目的]探讨N-乙酰-β-D-氨基葡萄糖苷酶对汞作业者肾脏损害的早期诊断意义。[方法]85名汞作业者分为汞接触正常组、汞接触超标组,并以无汞接触史的65名健康成人作为对照组。分别进行临床体检并测定尿汞(UHg)、血肌酐(BCr)、尿肌酐(UCr)、血尿素氮(BUN)、尿-N-乙酰-β-D-氨基葡萄糖苷酶(NAG),排除肾病史和患有肾脏疾病患者后对结果进行分析。[结果]汞作业者UHg和NAG均显著高于对照组,但BCr、UCr、BUN与对照组无显著差别。[结论]长期汞接触可造成肾功能损害,尿-N-乙酰-β-D-氨基葡萄糖苷酶可作为汞作业工人肾脏损害的早期敏感的诊断指标。[Objective]To study the significance of determination of N-acetyl-β-D-glucosaminidase for early diagnosis of renal damage in mercury workers.[Methods]Eighty-five mercury workers were divided into the 2 experimental groups：the group with the urinary mercury level higher than the normal value and the group with the urinary mercury level lower than the normal value.Sixty-five healthy adults with no mercury exposure history were assigned to the control group.All the subjects had no renal disease history and did not suffer from renal diseases at that time.The results from physical examinations and measurements of UHg,BCr,UCr,BUN and N-acetyl-β-D-glucosaminidase in all the groups were analyzed.[Results]The levels of UHg and N-acetyl-β-D-glucosaminidase were significantly higher in the 2 experimental groups than in the control group;however,the levels of BCr,UCr and BUN had no statistically significant difference between the experimental groups and the control group.[Conclusion]Exposure to mercury for a long time can cause renal damage.The level of N-acetyl-β-D-glucosaminidase can be used as a sensitive indicator for detecting early renal damage caused by mercury.

关 键 词：N-乙酰-Β-D-氨基葡萄糖苷酶 汞作业者 肾脏损害 早期诊断 

分 类 号：R135.11[医药卫生—劳动卫生]