头孢拉定与茜素红的荷移反应研究  

Study on the charge transfer reaction between Cefradine and alizarin red

作　　者：陈朝艳[1] 陈效兰[1] 霍欢[1] 杨娟[1] 

机构地区：[1]湘潭大学化学学院,湖南湘潭411105

出　　处：《化学试剂》2007年第10期602-604,共3页Chemical Reagents

基　　金：湖南省教育厅资助科研项目(05C082)

摘　　要：采用紫外可见分光光度法研究了头孢拉定与茜素红之间的荷移反应，建立了一种快速简便测定头孢拉定的荷移分光光度法。实验表明，在水溶液中头孢拉定与茜素红在室温条件下即可形成稳定的1∶1型荷移配合物，该配合物的λmax=520nm，表观摩尔吸光系数ε为4.7×10^3L·mol^-1·cma^-1。头孢拉定药物浓度在5×10^-6-5×10^-4mol/L范围内服从比尔定律，r=0.9999。相对标准偏差为0.60%（n=6），加标回收率为97.0%-99.5%。This paper studied the charge transfer reaction between Cefradine and alizarin red by UV-Vis speetrophotometry. A new method for the determination of Cefradine has been developed. At room temperature, Cefradine could react with alizarin red to form an 1 ： 1 complex in the presence of water, which made a maximum absorption peak at 520 nm. The molar absorptivity of the complex was 4.7 × 10^3 L·mol^-1· cm^-1 and the Beer＇s law was observed at a Cefradine concentration ranging from 5 × 10^- 6 mol/L to 5 × 10^-4 mol/L.The RSD was 0.60% （ n = 6） .The labeled recoveries were between 97.0% and 99.5%.

关 键 词：荷移反应 头孢拉定 茜素红 分光光度法 

分 类 号：O657.32[理学—分析化学]