6,7-二氢-5H-环戊烯并[b]吡啶的合成工艺改进  

An improved method for synthesizing 6,7-dihydro-5H-cyclopentenyl[b]pyridine

作　　者：冯泽旺[1] 孙成辉[1] 赵信岐[1] 

机构地区：[1]北京理工大学材料科学与工程学院

出　　处：《化学试剂》2007年第10期621-622,627,共3页Chemical Reagents

摘　　要：以1-氨基-2-氰基环戊烯(ACCP)为起始原料,经乙酰化、闭环、水解、氯化及脱氯等5步反应制得标题化合物。该方法反应条件温和,原料廉价易得,操作简便,适合工业化生产,总收率可达58.5%。6,7-Dihydro-5H-cyclopentenyl[b]pyridine was synthesized from 1-amino-2-cyanocyclopentene （ACCP） via acetylation, cyclization, hydrolysis, chlorination and dechlorination. The reaction condition of this method was simple and suitable for commercialization. The overall product yield was 58.5 % .

关 键 词：6 7-二氢-5H-环戊烯并[b]吡啶 中间体 头孢匹罗 

分 类 号：O626.321[理学—有机化学]