司他夫定缓释微丸胶囊的制备与体外释放度考察  

Preparation and the in vitro release of stavudine extended-release pellets capsules

作　　者：苏龙[1] 刘志东[1] 吴保祥 聂淑芳[1] 潘卫三[1] 

机构地区：[1]沈阳药科大学药学院,沈阳110016 [2]永信药品工业(昆山)有限公司,昆山215331

出　　处：《中国新药杂志》2007年第16期1279-1282,共4页Chinese Journal of New Drugs

摘　　要：目的:研制司他夫定缓释微丸胶囊。方法:采用溶液法以流化床包衣制备载药微丸,以Kollicoat SR30D为包衣液包覆缓释衣层,制成膜控缓释微丸,考察聚合物增重、后处理方法及致孔剂等因素对缓释微丸释放度的影响。结果:致孔剂可改善缓释微丸的时滞现象,药物释放速度随膜厚及后处理时间的增加而变慢。结论:司他夫定缓释微丸胶囊具有较好的释药性能,是一种较理想的口服缓释制剂。Objective：To prepare stavudine extended-release pellets capsules. Methods：The fluidized bed coating equipment was used to prepare pellets. Kollicoat SR 30D was used as a sustained-release coating material. The release rate of stavudine from the sustained-release pellets capsules were studled by comparing the increment in coating material weight, the treatment time and the amount of poremaking agent. Results：The poremaking agent improved the lag time of stavudine from the pellets. The release rate was reduced with the increase of thickness in the coating material and treatment time. Conclusions：Stavudine sustained-release pellets capsules show an evident sustained-release effect and may be suitable for oral administration as a sustained-release preparation.

关 键 词：缓释微丸 流化床包衣 司他夫定 体外释放度 

分 类 号：R943.41[医药卫生—药剂学] R978.7[医药卫生—药学]