老中青患者口服环孢素A后体内8项生化指标的三维分析  

Analysis of 3-dimension images of eight indicators in vivo within administration of cyclosporine A in elderly,middle-age and young patients

作　　者：王弘[1] 郭代红[1] 刘皈阳[1] 晏学民[2] 

机构地区：[1]中国人民解放军总医院药品保障中心,北京100853 [2]中国矿业大学(北京)化学与环境工程学院,北京100083

出　　处：《中国新药杂志》2007年第16期1310-1312,1313,I0001,共5页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(30472056)

摘　　要：目的:研究612名老年、中年与青年肾移植患者口服环孢素A后体内血红蛋白及7项血生化指标总胆红素、直接胆红素、血糖、钾、钠、血尿素氮、肌酐与服药天数的关系。方法:将老年、中年与青年患者的8项指标血红蛋白、总胆红素、直接胆红素、血糖、钾、钠、血尿素氮、肌酐与用药时间分为三组,采用MATLAB7.0分析得到对应的三维图像,计算体内8项均值、标准差并进行比较。结果:三维图像显示患者的8项指标与用药天数存在关系。结论:肾移植患者用药天数对体内8项指标有影响,所测指标对预防疾病有重要意义。Objective： To analyze the correlation between the dosing period of cyclosporine A and indicators in vivo such as Hb, IBI, DS, Glu, K^＋, Na^＋, BUN, Cr of 612 elderly, middle-age and young kidney transplantation recipients. The correlation was anatomized between dosage administration of cyclosporine A and the dosing period. Methods： 3-Dimension images of the data were parsed by MATLAB software for kidney transplantation recipients, according divided into three groups including Hb, DS, IBI; Glu, K^＋ , Na^＋ ; dosing period, BUN, Cr. The above eight indicators were analyzed and compared. Results： There appeared to be some connection between the 8 indicators in vivo and the dosing period of cyclosporine A from 3-dimension images. Conclusion： The dosing period of cyclosporine A can influence indicators in vivo in kidney transplantation recipients. Some indicators are important for preventing and treating disease.

关 键 词：肾移植 三维图像 环孢素A 体内指标 

分 类 号：R979.5[医药卫生—药品]