利用“层次分析”法对石榴叶鞣质及主要成分减肥降脂活性的综合评价  

An Evaluation of Anti-Obesity and Anti-hyperlipidemia of Pomegranate Tannins Using Hierarchy Program

作　　者：雷帆[1] 陶佳林[1] 苏慧[1] 邢东明[1] 林晗[1] 杜力军[1] 

机构地区：[1]清华大学生物科学与技术系药物药理研究室,北京100084

出　　处：《世界科学技术-中医药现代化》2007年第4期46-50,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金(30572340):用数学模型对石榴叶总鞣质及其主要活性成分对脂肪细胞作用的综合评价

摘　　要：利用层次分析软件,采用半数有效量(EC_(50))作为评价参数,对石榴叶总鞣质及其主要成分的减肥降脂作用效果进行拟合,分析了各成分的综合作用,找出了总鞣质中最具代表性的单体成分SY1,并在此基础上进一步验证了层次法分析软件的适用性。结果表明该软件能够有效地反映被评价成分的综合药效,并具有准确、简便易行、易操作等特点。Using Hierarchy Evaluation Calculating Program （HECP） as a tool, a comprehensive pharmacological evaluation was made in vitro of the anti - obesity and anti - hyperlipidemia effects of total tannins and other medicinal elements in pomegranate leaves, based on EC50 as candidate data. Results showed that SY1 was a most important ingredient in the total tannins. The study also showed that the program was easy for operation with a clearly defined procedure and reliable results.

关 键 词：药效评价 层次分析法 石榴叶 减肥降脂 

分 类 号：R284.2[医药卫生—中药学]