左氧氟沙星注射剂的稳定性  

Study on the stability of levofloxacin injection

作　　者：顾洪安[1] 沈浩[1] 张曙华[1] 张晋[2] 李水军[3] 余琛[3] 

机构地区：[1]上海市徐汇区中心医院药剂科,上海200031 [2]上海中医药大学中药学院 [3]上海市徐汇区中心医院中心实验室,上海200031

出　　处：《中国临床药学杂志》2007年第5期311-314,共4页Chinese Journal of Clinical Pharmacy

摘　　要：目的考察左氧氟沙星注射剂的稳定性。方法采用紫外分光光度法及LC-MS/MS法测定注射剂中盐酸左氧氟沙星的含量,考察了温度及光照等因素对5种市售左氧氟沙星注射剂稳定性的影响。结果随放置时间的延长,左氧氟沙星注射剂在5、20、30℃避光条件放置12 h含量基本保持稳定;在4 500 lx光照条件18℃放置12 h含量基本保持稳定。结论实验环境因素对该5种左氧氟沙星注射剂的稳定性无显著影响。AIM To investigate the stability of levofloxacin injection. METHODS The concentration of levofloxacin in five injections was determined by ultraviolet spectrophotometry and LC-MS/MS methods. The effects of temperature and light on the stability of the levofloxacin injections were investigated. RESULTS The levofloxacin injections were stable when placed at 5℃ ,20℃ and 30℃, and under the condition of 4 500 lx at 18℃ for 12 h. CONCLUSION There is no significant influence of the environmental factors on the stability of the five levofloxacin injections.

关 键 词：左氧氟沙星 注射剂 稳定性 

分 类 号：R927.11[医药卫生—药学]