亚胺培南/西司他丁对严重感染患者肾脏功能的影响  

Effect of Imipenem/cilastatin on Renal Function in Patients with Severe Infection

作　　者：侯立朝[1] 熊利泽[1] 尚磊[1] 李淑霞 陈绍洋[1] 王雅丽[1] 胡文能[1] 霍婷婷[1] 王一楠[1] 刘菲[1] 朱菲[1] 李娜[1] 申洁[1] 李慧[1] 

机构地区：[1]第四军医大学西京医院,陕西西安710032 [2]漯河市中医院,河南漯河462000

出　　处：《中华医院感染学杂志》2007年第9期1135-1137,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析亚胺培南/西司他丁用于抗感染治疗时对肾脏功能的影响。方法对严重肺部感染患者45例进行回顾性分析,按照使用亚胺培南/西司他丁时间的长短不同分为A、B、C 3组。结果治疗后,所有患者血尿素氮(BUN)和肌酐(CRE)、尿白蛋白(U-ALB)和β2微球蛋白定量(Uβ2-MG)均有所下降(P<0.01),其中U-ALB和Uβ2-MG仍高于正常,但这种变化组间比较差异均无统计学意义(P>0.05)。结论亚胺培南/西司他丁用于治疗严重感染时,不影响患者肾功的恢复。OBJECTIVE To retrospectively study the effect of imipenem/cilastatin on the renal function in the patients with severe infection. METHODS Forty-five patients with septic shock were divided into such three groups as Group A, Group B and Group C according to the difference in the duration of imipenem/cilastatin used. RESULTS With therapy, blood urea nitrogen, blood creatinine, urine albumin and urine β2 microgtobulin output in all patients declined significantly （P〈0.01）, and of all, urine albumin and urine β2 microglobulin output were still abnormal in all patients, and the changes in the above indices with the time had no statistically significant difference among the three groups （P 〉 0. 05）. CONCLUSIONS Imipenem/cilastatin could not influence the restoration of the renal function in the patients with severe infection.

关 键 词：严重感染 亚胺培南/西司他丁 肾脏功能 

分 类 号：R978.1[医药卫生—药品]