江苏南通地区变应性鼻炎遗传流行病学研究  

Genetic epidemiological study on allergic rhinitis in Nantong region of Jiangsu Province

作　　者：马莉[1] 陈大灵 章如新[3] 汪晓雷[1] 施云剑 季超[1] 黄志俊[1] 钱茂华[1] 王卫华[1] 管沛[1] 

机构地区：[1]南通大学第二附属医院耳鼻咽喉科,226001 [2]南通市疾病控制中心慢性病科 [3]第二军医大学附属长海医院耳鼻喉科

出　　处：《中华耳鼻咽喉头颈外科杂志》2007年第9期643-646,共4页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

基　　金：江苏省卫生厅重点资助科研项目(H9929 S9918)

摘　　要：目的研究遗传因素在变应性鼻炎(allergic rhinitis,AR)发病中的作用。方法采取分阶段抽样的方法对江苏省南通地区23 825户家庭,95 300人进行了 AR 的患病现状调查,通过遗传流行病学研究,应用 Li-Mantel-Gart 和 Falconer 方法进行 AR 分离比及遗传度的估算。结果江苏省南通地区 AR 的患病率为1.20%(男1.21%,女1.18%,两者相比差异无统计学意义)。根据先证者同胞组的资料计算,其分离比为0.078,明显低于单基因遗传理论分离比(0.25),属于多基因遗传方式。AR 先证者Ⅰ、Ⅱ、Ⅲ级亲属遗传度分别为(82.6±2.19)%、(80.8±2.93)%、(78.4±7.04)%,加权平均遗传度为(81.86±1.70)%。在 AR 先证者家系三级亲属中 AR 患病率依次为:Ⅰ级亲属(12.11%)>Ⅱ级亲属(5.12%)>Ⅲ级亲属(2.75%)>一般人群(1.20%)。结论 AR 的发生存在家族聚集倾向性。AR 的发病是由多个基因和环境因素共同作用的结果,符合多基因遗传疾病特征。Objective To explore the effects of genetic factors on the occurrence of allergic rhinitis （AR）. Methods The morbidity rate of AR was surveyed by multistage sampling among 95 300 individuals （23 825 families） in Natong region, Jiangsu province . And a genetic epidemiologic investigation on AR was carried out to estimate the segregation ratio and heritability （ h^2 ） of AR by the methods of Li-Mantel-Gart and Falconer respectively. Results The morbidity rate of AR in Natong region was 1.20% （Male 1.21%, Female 1.18%, no statistical significance between them） ; By the data of the AR ancestry, the segregation ratio of AR in Nantong region was 0. 078, significantly less than 0. 25, and the genetic model belonged to polygenetics. The 1st, the 2nd, and the 3rd generation h^2 of AR were （82. 6 ±2. 19）%, （80. 8 ±2.93）%, （78.4 ± 7.04） % . The h^2 of AR was （ 81.86±1.70） %. In the ancestry of AR, the morbidity rate of the 1 st generation with AR was 12. 11% ; the 2nd generation with AR was 5. 12% ; the 3rd generation with AR was 2.75% ; and the morbidity rate of AR in general population was 1.20%. Conclusions The heredity in family with AR is obvious. Several genes plus the environmental factors may cause AR, which accords with the characteristics of the polygene heredity disease.

关 键 词：鼻炎 变应性 流行病学因素 分离比 遗传度 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]