Detection of two amino acid deletions in HIV-1 Nef protein from Chinese former paid blood donors  

作　　者：SONG Yan-hui WEI Min MA Peng-fei XING Hui SI Xue-feng TANG Hai-li LI Hui-guang SHAO Yi-ming 

机构地区：[1]Wuhan Institute of Virology, Chinese Academy of Sciences,Wuhan 430071, China [2]Graduate School of the Chinese Academy of Sciences, Beijing100039, China [3]State Key Laboratory for Infectious Disease Control andPrevention, National Center for AIDS/STD Control andPrevention, Chinese Center for Disease Control and Prevention,Beijing 100050, China

出　　处：《Chinese Medical Journal》2007年第18期1635-1638,共4页中华医学杂志（英文版）

基　　金：the NIH CIPRA(No.1U19 A151915-03);the "973" National Key Project (No.G1999054107);the National Outstanding Youth Grant(No.39925030).

摘　　要：HIV-1 Nef protein plays an important role in HIV-1 pathogenesis, including downregulation of the cell surface CD4 and class I major histocompatibility complex （MHC）, enhancement of virion infectivity and alteration of a variety of cellular signal transduction pathways.1.2 A recent report demonstrated that Nef down-regulates dendritic cell surface expression of MHC class I and up-regulates molecules known to be critical for apoptosis induction, such as TNF-α and FasL^3 It is also very interesting that Nef expression alone may be sufficient to cause an AIDS-like disease in transgenic mice.2 In many human cohort studies it has been reported that long-term nonprogressors （LTNPs）, who remain asymptomatic for more than one decade without antiretroviral therapy, harbored nef-deleted viruses.4-7 Intense studies on nef genes from LTNPs have been done in Europe and United States but none of such studies have been done in China.HIV-1 Nef protein plays an important role in HIV-1 pathogenesis, including downregulation of the cell surface CD4 and class I major histocompatibility complex （MHC）, enhancement of virion infectivity and alteration of a variety of cellular signal transduction pathways.1.2 A recent report demonstrated that Nef down-regulates dendritic cell surface expression of MHC class I and up-regulates molecules known to be critical for apoptosis induction, such as TNF-α and FasL^3 It is also very interesting that Nef expression alone may be sufficient to cause an AIDS-like disease in transgenic mice.2 In many human cohort studies it has been reported that long-term nonprogressors （LTNPs）, who remain asymptomatic for more than one decade without antiretroviral therapy, harbored nef-deleted viruses.4-7 Intense studies on nef genes from LTNPs have been done in Europe and United States but none of such studies have been done in China.

关 键 词：human immunodeficiency virus NEF disease progression 

分 类 号：R512.91[医药卫生—内科学]