超量、低浓度利多卡因皮下灌注后血浆药物代谢动力学研究  

A pharmacokinetic study of lidocaine in patients undergoing liposuction with tumescent technique

作　　者：赵宇[1] 宋业光[1] 薛富善[2] 徐君 吕纹[3] 

机构地区：[1]中国医学科学院中国协和医科大学整形外科医院,北京100041 [2]中国医学科学院中国协和医科大学整形外科医院麻醉科 [3]北京协和医院血药监测室

出　　处：《中华整形烧伤外科杂志》1997年第1期63-65,共3页

摘　　要：为探讨皮下超量灌注吸脂术的安全性如何,通过分段采血方法测定血利多卡因浓度观测其药物代谢动力学(以下简称药代动力学)变化。研究结果表明:利多卡因的吸收缓慢,血浆波峰浓度平均1.16μg/ml,一般在皮下灌注后4～13小时出现。波峰浓度(Y:μg/ml)与利多卡因用量(X:mg/kg)明显相关,相关方程式:Y=-0.494+0.071X,r=0.934,P<0.001。认为皮下超量灌注吸脂术是安全、有效的去脂方法。The purpose of this study was to evaluate the pharmacokinetics of lidocaine in the pa- tients undergoing liposuction after subcutaneous infiltration of 0.06% lidocaine.It was found that the absorption of lidocaine was slow.The mean peak concentration of lidocaine that was 1.16ug/mg with a range of 0.67 to 2.84ug/mg occurred 4—13 hours after lidocaine administration.The peak concentration (Y) was correlated with the dose(X) of lidocaine,which was drawn as Y=-0.494+0.071X.(r= 0.934,P<0.001).We concluded that the tumescent technique is an effective and safe method for the patients undergoing liposuction.

关 键 词：利多卡因 皮下灌注 药代动力学 超量灌注吸脂术 

分 类 号：R971.2[医药卫生—药品]