人体正常皮肤及增生性瘢痕胶原酶活性的检测  

Observation of collagenase activity in hypertrophic scar and normal skin in burned patient

作　　者：管正玉[1] 程洪伟[1] 孙广慈[1] 申志惠 

机构地区：[1]中国医学科学院中国协和医科大学整形外科研究所,北京100041

出　　处：《中华整形烧伤外科杂志》1997年第2期112-114,共3页

摘　　要：为探讨胶原降解代谢在增生性瘢痕形成中的作用,对23例患增生性瘢痕的成年病人的瘢痕组织(其中8例经病理检查)及正常皮肤的胶原酶活性作了检测和比较观察。检测结果:瘢痕组织的胶原酶活性平均值为197.09±48.10(U),正常皮肤胶原酶活性平均值为73.17±13.71(U),二者差异有非常显著意义(P<0.01)。表明增生性瘢痕的形成不仅与胶原的过度合成与沉积有关,同时与胶原降解代谢减少有关。Collagenase activity in hypertrophic scars(HS)and normal skin(NS)of 23 burned pa- tients was detected by eleetrophoretic technique.It was found that the average value of the enzymatic activity was 197.07±48.10(U)and 73.17±13.71(U)in HS and NS respectively.The difference was significant(p<0.01).The results indicated that degradation metabolism of collagen related to the for- mation of hypertrophic scar.The authors discussed the possibilities of degradation metabolic distur- bance of hypertrophic scar and its treatment.

关 键 词：胶原酶 增生性瘢痕 胶原降解代谢 

分 类 号：R619.6[医药卫生—外科学]