基于多排螺旋CT正常肺动脉分支的流态模拟  

Flow simulation of normal pulmonary artery branches based on multiple detectors computed tomography

作　　者：王丽华[1] 张文普[2] 姜卫香[1] 钱玉娥[1] 郭佑民[3] 

机构地区：[1]浙江大学医学院附属邵逸夫医院放射科,杭州310016 [2]浙江大学航空航天学院流体工程研究所 [3]北京朝阳医院放射科

出　　处：《中华医学杂志》2007年第36期2534-2536,共3页National Medical Journal of China

基　　金：国家自然科学基金(30400110)

摘　　要：目的利用多排螺旋 CT(MDCT)的 CT 肺动脉造影(CTPA)图像及超声流态数据与流体力学软件相结合初步模拟正常人主肺动脉及左右肺动脉分支内流动状态。方法选择正常胸部心电门控 CTPA 图像,分别进行心脏收缩期及舒张期薄层多平面重建,在 InSpace 肺动脉重建坐标图中做手动分割,用 GAMBIT 软件生成网格,将超声测量数据导入 Fluen t软件进行数值计算和流态模拟。结果正常肺动脉分支不同心动周期流动状态不同,收缩期较舒张期压力高,流速快,右肺下叶动脉承受双期压差最大,段动脉双期流速差别不大。结论右肺下叶动脉是肺动脉压力升高是受累较早者;利用 CTPA 图像结合相关模拟软件研究肺动脉分支内血流变化是可行的。Objective To simulate the flow condition in the main pulmonary artery and the branches of left and right pulmonary arteries by combining the images from CT pulmonary angiography （CTPA） by multiple detectors computed tomography （MDCT） and the flow condition data from ultrasonic cardiography. Methods The normal enhanced chest CTPA images with ECG-gating from 25 persons undergoing physical examination, 21 males and 4 females, aged 39, underwent thin-slice multiple plane reconstruction in diastolic and systolic periods respectively. These images were stored in the InSpace software. On the base of coordinates GAMBIT software was used to generate the nodes and meshes. FLUENT software was used to simulate the blood flow speed and pressure field distribution. Results The pressure levels of the main pulmonary artery and the branches of left and right pulmonary arteries were higher during the systolic period. The blood flow velocity was faster during the systolic period too. The right lower lobe artery endured the most significant pressure during both systolic and diastolic periods. However, there were not significant differences in pressure and blood flow velocity between the systolic and diastolic periods in the segmental arteries. Conclusion The right lower lobe artery is the first part to be affected when the pulmonary pressure rises. It is feasible to study the changes of the flow condition in the branches of pulmonary artery through combining CTPA images and relevant sofiwares.

关 键 词：肺动脉 体层摄影术 X线计算机 计算机模拟 

分 类 号：R816.2[医药卫生—放射医学]