Synthesis of New Ligand 1,2-Bis{di[(R,R)-1,3,2-oxzaphosphlidine]phosphino}ethane with C_2-symmetric Axis and Application in Rh-catalyzed Asymmetric Hydrogenation  

作　　者：GONG Da-chun ZHOU Hua WEI Ping OUYANG Ping-kai 

机构地区：[1]College of Chemistry and Life Science, China Three Gorges University, Yichang 443001, P. R. China [2]College of Life Science and Pharmacy, Nanfing University of Technology, Nanfing 210009, P. R. China

出　　处：《Chemical Research in Chinese Universities》2007年第5期544-548,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Basic Research Program of China(No.2003CB716000).

摘　　要：New ligand 1,2-bis{di[（R,R）-1,3,2-oxzaphosphlidine]phosphino}ethane [（R,R）-BDOPPEs 1,2,3 and 4] with C2-symmetric axis and bearing nitrogen and oxygen were synthesized from readily available optically active amino alcohols.Rh complexes with these ligands were highly enantioselective catalysts for asymmetric hydrogenation of N-benzoyldehydroamino acid derivatives and α-functionalized ketones in 99%e.e.and 98%e.e.,respectively.This new class of（R,R）-BDOPPEs 1,2,3 and 4 gave much more effectivity and enantionselectivity than their corresponding non-C2-asymmetric aminophosphine phosphinite.New ligand 1,2-bis{di[（R,R）-1,3,2-oxzaphosphlidine]phosphino}ethane [（R,R）-BDOPPEs 1,2,3 and 4] with C2-symmetric axis and bearing nitrogen and oxygen were synthesized from readily available optically active amino alcohols.Rh complexes with these ligands were highly enantioselective catalysts for asymmetric hydrogenation of N-benzoyldehydroamino acid derivatives and α-functionalized ketones in 99%e.e.and 98%e.e.,respectively.This new class of（R,R）-BDOPPEs 1,2,3 and 4 gave much more effectivity and enantionselectivity than their corresponding non-C2-asymmetric aminophosphine phosphinite.

关 键 词：（R  R） -BDOPPE C2-Symmetry Asymmetric catalytic hydrogenation 

分 类 号：O627.51[理学—有机化学]