隔姜灸治疗化疗所致白细胞减少症:多中心随机对照研究  

Multi-central clinical valuation of ginger-partitioned moxibustion for treatment of luekopenia induced by chemotherapy

作　　者：赵喜新[1] 路玫[1] 朱霞[2] 高萍[3] 李艳丽[4] 王雪梅[5] 马东阳[2] 郭现辉[1] 童伯瑛[1] 杨晓丽[3] 杜炜炜[4] 周世繁[4] 刘怀民[2] 冉鹏飞[1] 吕晓蕊[1] 

机构地区：[1]河南中医学院第三附属医院针灸科,郑州450008 [2]河南省肿瘤医院 [3]河南中医学院第一附属医院 [4]河南省中医院 [5]河南省人民医院

出　　处：《中国针灸》2007年第10期715-720,共6页Chinese Acupuncture & Moxibustion

基　　金：国家中医药管理局中医诊疗技术整理与研究项目:国中医药科2002ZL26

摘　　要：目的:观察隔姜灸治疗化疗所致白细胞减少症的疗效及对肿瘤患者化疗后生存质量的影响。方法:采用多中心协作对照的方法,将符合纳入标准的病人随机分为两组,隔姜灸组用隔姜灸,穴取大椎、膈俞、脾俞等;中药组口服参花片、强力升白片。观察2组病人白细胞减少情况、消化道反应情况以及化疗药物副作用情况。结果:隔姜灸组113例,中药组108例。10天后疗效:隔姜灸组治愈率为84·1%,有效率为66·4%;中药组分别为35·2%、33·3%。2组比较,差异均有非常显著性意义,均P<0·01。15天随访2组均能维持疗效。2种治疗方法均能改善临床症状,但隔姜灸组优于中药组。安全性指标检验表明,2组均未出现不良反应,反而对化疗所致的心、肺、肾功能的损伤有一定的改善。结论:隔姜灸治疗化疗所致白细胞减少症疗效可靠并优于口服中成药,具有较好的可重复性。Objective To prove the therapeutic effect of ginger-partitioned moxibustion on luekopenia induced by chemotherapy and effect on life quality of the patient with tumor after chemotherapy. Methods Randomized, controlled, multi-central cooperative method was used and the patients confirmed to the enrolled criteria were divided into two groups. The test group were treated with ginger-partitioned moxibustion at Dazhui （GV 14）, Geshu （BL 17）, Pishu （BL 20）, etc. ; and the control group with oral administration of Chinese patent medicine. Results Out of the 221 cases confirmed to program analysis, 113 cases were in the test group and 108 cases in the control group. After 10 days, the cured rate and the effective rate were 84.1% and 66.4 % in the test group and 35.2 % and 33.3 % in the control group, respectively, with very significant differences between the two groups （both P〈0.01） ; fifteen days later, the therapeutic effects in the two groups were maintained. The two methods could improve clinical symptoms, with the test group being better than the control group. Any adverse response was not found in the two groups, and the injuries of functions of the heart, lung and kidney induced by chemotherapy had some improvement. Conclusion The therapeutic effect of ginger-partitioned moxibustion on luekopenia induced by chemotherapy is reliable and is better than oral administration of Chinese patent medicine, with a better duplication.

关 键 词：隔姜灸 化疗反应/针灸疗法 白细胞减少/针灸疗法 多中心研究 

分 类 号：R246.1[医药卫生—针灸推拿学]