胶束增强型聚电解质胶囊对罗丹明B的包埋和释放  

Encapsulation and Release of the Micelles-enhanced PE Capsules Filled with Rhodamine B

作　　者：李晓东[1] 沈家骢[2] 

机构地区：[1]浙江大学医学院附属口腔医院,杭州310006 [2]浙江大学高分子复合材料研究所,杭州310027

出　　处：《高等学校化学学报》2007年第10期2000-2005,共6页Chemical Journal of Chinese Universities

基　　金：国家'九七三'计划项目(批准号:2005CB623902);国家自然科学重点基金(批准号:50333020);浙江省自然科学基金(批准号:Y205183)资助.

摘　　要：研究了胶束增强型的聚电解质胶囊对正电荷小分子罗丹明B的包埋和释放情况.胶囊对正电荷水溶性物质罗丹明B的包埋动力学和包埋量的研究结果表明,这种胶束增强型聚电解质胶囊能够快速而高效地包埋水溶性物质.释放研究结果表明,胶囊在不同的pH条件下的释放行为有一定的区别,但趋势相同,分为突释区、释放诱导区、快速释放区和缓释区,呈现多区释放,前期胶囊的突释现象相当明显.同时,盐离子的浓度对胶囊的释放行为影响不大.The encapsulation of ＂micelles-enhanced＂ polyelectrolyte capsules to Rhodamine B, a positively charged small molecule, and in vitro release behavior of Rhodamine B containing capsules, were studied. Studies on the encapsulation kinetics and loading amount of capsules to water-soluble Rhodamine B suggest that water-soluble substances can be efficiently entraped into this type of ＂micelles-enhanced＂ polyelectrolyte capsules. In vitro release tests suggest that there were difference in release behavior between Rhodamine B-containing capsules that performed in release media with various pH values. However, for these release profiles, a similar trend was displayed, and the whole release curves have several periods with different Rhodamine B release rates, which include a burst release, a lag period, a rapid release phase and a sustained release stage. The burst release in the first stage was significant, which should be ameliorated in the following study. Simultaneously, ion strength seemed to have no significant effect on the release behavior of Rhodamine B-loaded capsules.

关 键 词：LbL技术 聚电解质微胶囊 胶束增强 高效包埋 释放曲线 

分 类 号：O631[理学—高分子化学] TB383[理学—化学]