黏附分子E-选择素A128C基因多态性与冠心病的关系  

Correlation between E-selectin A128C gene polymorphism and coronary heart disease

作　　者：饶丹[1] 姜红[2] 曾秋棠[3] 郭和平[3] 王敏[3] 李明慧[3] 葛均波[2] 

机构地区：[1]武汉亚洲心脏病医院心内科,湖北武汉430022 [2]复旦大学中山医院心内科 [3]华中科技大学同济医学院心血管病研究所

出　　处：《心脏杂志》2007年第5期547-549,555,共4页Chinese Heart Journal

基　　金：教育部留学人员基金项目资助(No.教外司留[2002]247号)

摘　　要：目的研究中国汉族人群黏附分子E-选择素(E-selectin)基因外显子4,128编码处碱基A/C多态性与冠心病(CHD)的相关关系,探讨通过黏附分子E-selectin基因型筛选CHD易患人群和高危人群的可能性。方法入选145例CHD患者,其中73例为急性冠脉综合征(ACS),72例为稳定型冠心病(SCHD),并入选144例为对照组。所有CHD患者均经冠状动脉造影证实。采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,分析E-选择素基因型。结果与对照组相比,ACS患者和SCHD患者的E-选择素基因型频率和等位基因频率差异均有显著性。基因型频率的相对风险分析发现,CC+AC基因型患冠心病的风险是AA基因型的5.843倍(OR=5.843,95%C I:3.066-11.133)。结论E-选择素基因A/C多态性与CHD相关,C等位基因可能是CHD发病的遗传易感基因。AIM To study the correlation between E-selectin gene polymorphism in exon 4 codon 128 and coronary heart disease （CHD） in Chinese HaM population and the possibility of using the gene type to screen the susceptible and high-risk CHD population. METHODS The genotypes of E-selectin were detected by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） in 145 CHD cases, including 73 with acute coronary syndrome （ACS） patients and 72 cases with stable coronary heart disease （SCHD）, and 144 controls. RESULTS There was significant difference in the frequencies of genotype and allete in A/C polymorphism between CHD and control group, and between ACS and SCHD respectively（ P 〈0.01 and P 〈 0.05 ）. The relative CHD risk in those with genotype CC ＋ AC was 5. 843 times that in those with genotype AA （OR = 5. 843, 95% CI： 3. 066-11. 133 ）. CONCLUSION E-selectin gene A/C polymorphyism is significantly associated with the occurrence, development and severity of CHD. C allele of E-selectin may be a genetic factor that may determine an individual＇s susceptibility to CHD.

关 键 词：冠状动脉疾病 E-选择素 基因多态性 限制性片段长度 

分 类 号：R541.4[医药卫生—心血管疾病]