左旋氨氯地平对原发性高血压患者颈动脉内-中膜厚度的逆转作用  

The reversal role of levamlodipine on carotid artery intima-media thickness in patients with essential hypertension

作　　者：鲁永菊[1] 刘先哲[2] 周蜜[1] 汪昌清[1] 

机构地区：[1]湖北省三峡大学护理学院心内科,湖北宜昌443000 [2]湖北宜昌市第一人民医院心内科

出　　处：《临床心血管病杂志》2007年第9期649-651,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨左旋氨氯地平对原发性高血压患者颈动脉内-中膜厚度(IMT)的影响。方法:将76例原发性高血压患者随机分为试验组和对照组,对照组常规使用利尿剂和卡托普利治疗,试验组在对照组基础上加用左旋氨氯地平2.5mg,qd,均治疗8周,比较2组颈动脉IMT、血压、心率、空腹血糖及TG、TC、HDL-C和LDL-C的变化。结果:试验组颈动脉IMT、收缩压及舒张压水平均显著降低,与治疗前及对照组比较均差异有统计学意义(均P<0.05)。血脂各指标、血糖、心率2组间均差异无统计学意义。结论:左旋氨氯地平具有良好的降压作用,同时对原发性高血压患者颈动脉IMT增加具有逆转作用。Objective： To discuss the reversal role of levamlodipine on carotid artery intima-media thickness （IMT） in patients with essential hypertension. Method：Seventy-six patients with essential hypertension were randomly divided into test and control groups. Control group conventionally used diuretics and captopril, the control group based on the control group, the test group was added to use 7.5 mg levamlodipine ereryday for 8 weeks. The differences were observed between two groups in carotid artery IMT, blood pressure, fasting serum triglyceride total cholesterol, high-density lipoprotein cholesterol and low density lipoprotein cholesterol. Result： After eight weeks of therapy test group significantly decreased carotid artery IMT sysedic blood pressure and diastolic blood pressure. There were significant differences between pre-treatment and after treatment, also significant differences between test group and concrol group. There were no significant differences in lipid parameters. Conclusion： Levamlodipine can decruse blood pressure well, and reversal carotid artery intima-media thickness of patients with essential hypertension.

关 键 词：高血压 动脉硬化 左旋氨氯地平 血管中膜 

分 类 号：R544.1[医药卫生—心血管疾病]