基质金属蛋白酶-9基因C1562T多态性与高血压颈动脉粥样硬化关系  

Relationship between matrix metalloproteinase-9 polymorphism C1562T and carotid artery arteriosclerosis in patients with essential hypertension

作　　者：唐礼江[1] 江建军[1] 陈晓锋[1] 朱敏[2] 林仙芳[3] 方崇峰[1] 沈卫峰[4] 

机构地区：[1]浙江省临海市温州医学院附属台州医院心内科,浙江临海317000 [2]浙江省临海市温州医学院附属台州医院中心实验室 [3]浙江省临海市温州医学院附属台州医院超声室 [4]上海第二医科大学附属瑞金医院心脏科

出　　处：《临床心血管病杂志》2007年第9期655-657,共3页Journal of Clinical Cardiology

摘　　要：目的：研究基质金属蛋白酶-9（MMP-9）基因C1562T多态性与高血压颈动脉粥样硬化的相关性。方法：原发性高血压患者120例,测定受试者双侧颈动脉内-中膜厚度（IMT）,IMT≥1.3mm认为存在粥样硬化斑块。依颈动脉有无粥样硬化分为颈动脉粥样硬化组、颈动脉正常组。用聚合酶链反应-限制性片段长度多态性分析法分析2组患者的MMP-9基因C1562T的多态性。结果：颈动脉粥样硬化组与颈动脉正常组CT＋TT基因型频率分别为28.8%、13.2%,差异有统计学意义（χ^2=4.488,P=0.034）,T等位基因与颈动脉粥样硬化发病密切相关（OR=2.092,95%CI：0.991-4.419,P=0.047）。结论：MMP-9T等位基因与高血压颈动脉粥样硬化密切相关,可能是其遗传标志。Objective： To investigate the relationship between matrix metalloproteinase-9 （MMP-9） polymorphism C1562T and carotid artery arteriosclerosis in patients with essential hypertension （EH）. Method： Intimalmedial thickness（IMT） was determined by B ultrasound in 120 patients with EH. Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism for screening C1562T polymorphism of the MMP-9 gene. Result： The results of polymorphisms analysis showed that the frequency of C/T and T/T genotypes of the C1562T polyporphism （28.8 %） in hypertension patients with carotid artery arteriosclerosis was significant ly higher than that in those who were without carotid artery arteriosclerosis （13. 2 %）. Individuals with EH carrying the -1562T allele had 2-fold higher risk of carotid artery arteriosclerosis （OR ： 2. 092,95% CI ： 0.991 - 4.419）. Conclusion：Present findings suggest that MMP-9 gene polymorphism （C1562T） may be a risk of carotid artery arteriosclerosis in patients with EH.

关 键 词：高血压 基因多态性 基质金属蛋白酶-9 动脉粥样硬化 

分 类 号：R544.1[医药卫生—心血管疾病]