MELD评分评估肝硬化肝功能储备力的临床研究  

Evaluation of hepatic functional reserve using MELD scoring system in patients with liver cirrhosis

作　　者：赵玉石[1] 韩德恩[2] 邰升[2] 周令望[3] 钟翔宇[2] 姜明山[2] 

机构地区：[1]哈尔滨医科大学附属第四医院胸心血管外科,哈尔滨市150001 [2]哈尔滨医科大学附属第二医院肝胆胰腔镜外科 [3]哈尔滨医科大学克山病研究所图像室

出　　处：《中华肝胆外科杂志》2007年第9期585-587,共3页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的准确评估肝储备功能可大大促进肝胆外科的发展，本实验旨在通过MELD评分与Child-Pugh分级及肝纤维化定量评估间关系的研究，了解MELD评分系统对评估肝硬化病人肝功能储备力的价值。方法通过对19例正常对照组和23例肝炎后肝硬化肝病组病人术前测定MELD评分，同时采用计算机辅助数字图像分析法检测正常对照组和肝病组病人肝组织标本的纤维化程度，分析MELD评分与Child-Pugh分级及肝纤维化定量评估间的关系。结果肝硬化病人MELD评分与肝纤维化面积百分比间呈正的直线相关关系（r=0．84，P〈0．01），Child A、B、C三组间MELD评分亦具有显著性差异（P〈0．01）。结论MELD评分是评估肝硬化病人肝储备功能的较好方法。Objective To investigate the value of MELD scoring system in predicting hepatic functional reserve in patients with liver cirrhosis. Methods By calculating MELD score in 23 patients with liver cirrhosis and 19 normal controls before operation and evaluating quantitative values of fibro sis of liver specimens after operation by computer-assisted digital image analysis, correlation among MELD and Child-Turcotte-Pugh classification and the percentage of fibrosis was analyzed. Results The positive linear correlation （r= 0.84） was found between MELD score and the values of the percentage of hepatic fibrosis in the patients with liver cirrhosis, and the correlation was significant at the level of 0.01. Differences of MELD score among the three groups （Child Pugh A, B and C） were statistically significant （P〈0.01）. Conclusion MELD scoring system can be used to predict the hepatic functional reserve in patients with virus-related liver cirrhosis.

关 键 词：肝储备功能 MELD评分 肝硬化 

分 类 号：R686[医药卫生—骨科学]