丁公藤注射液在家兔体内的药代动力学研究  

Pharmacokinetics of Caulis Erycibes Injection in Rabbits

作　　者：周燕文[1] 李梅[1] 赵素荣 

机构地区：[1]广西医科大学第一附属医院

出　　处：《中国中药杂志》1997年第3期179-181,共3页China Journal of Chinese Materia Medica

摘　　要：报道丁公藤注射液在家兔体内的药代动力学过程，采用荧光检测的反相高效液相色谱法测定丁公藤注射液有效成分东莨菪内酯在血中的浓度。东莨菪内酯在家兔体内呈现双峰现象，吸收较快，个体差异大，平均第一峰达峰时间：Ｔｍａｘ１＝（８．０８±３．８８）ｍｉｎ，第一峰浓度ＬＣｍａｘ１＝（１４５．４５±４７．６５）ｎｇ／ｍｌ。第二峰达峰时间：（２．４５±１．７９）ｈ，第二峰浓度为（４８．６６±４１．６６）ｎｇ／ｍｌ。其它的药代动力学参数为：Ｋｅ＝（０．５６±０．３７）ｈ－１，Ｔ１／２＝（１．８１±１．１４）ｈ，ＭＲＴ＝１５６．６１±９８．４１，ＣＬ／Ｆ＝（２２０．５４±１０９．３５）ｍｌ／ｍｉｎ，Ｖｄ／Ｆ＝（３０．４９±１９．３４）Ｌ，ＡＵＣ＝（８．５２±５．１５）μｇ．ｍｉｎ／ｍｌ。对于产生双峰现象的原因进行了讨论。The pharmacokinetics of single im doses of Caulis Erycibes injection in ten rabbits was studied. The concentration of scopoletin one of the effective components in Caulis Erycibes injection in serum was analyzed by high performance liquid chromotography with fluorescence monitor. In eight of ten rabbits a second peak was found on the serum concentration time curve. The absorption of scopoletin was quick with T max 1=8.08±3.88min,C max l=145.45±47.65ng/ml.The time to the second peak concentration (T max 2) was 2.45±1.79h,C max 2=48.66±41.66ng/ml. The other parameters were as follows: Ke=0.56±0.37h -1 , T 1/2 =1.81±1.14h, MRT=156.61±98.41, CL/F=220.54±109.35ml/min, Vd/F=30.49±19.34L, AUC=8.52±5.15μg· min/ml. The reason for the appearance of double peaks was discussed.

关 键 词：丁公藤注射液 东莨菪内酯 药代动力学 

分 类 号：R286.11[医药卫生—中药学] R285.5[医药卫生—中医学]