温阳和补气药对虚寒证大鼠神经内分泌的影响  

The Effect of Yang Warming and Qi Tonifying Natural Products on Neuroendocrine of Deficiency Cold Rats

作　　者：宋辉[1] 梁月华[1] 

机构地区：[1]北京医科大学中西医结合研究室

出　　处：《中国中药杂志》1997年第3期182-184,共3页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金

摘　　要：用大鼠喂知母、石膏汤制造虚寒证模型，停止喂药后虚寒状态持续７日以上，是研究药物治疗的好模型。用附姜和参芪方治疗３日，血清ＤβＨ，肾上腺内皮质素，脑ＮＥ，ＤＡ含量均提高，降低５ＨＴ含量，７日更显著。两复方在周缘和中枢均能兴奋交感神经内分泌系统。参芪方作用快但不持久，附姜方作用持久。The rat fed with the compound drug Zhi Mu and Shi Gao was made into an animal model of deficiency cold syndrome. The deficiency cold state was kept for more than 7 days after stopping the drug. So the animal model is good for studing the therapeutic effect of products of heat nature. After 3 therapeutic days with Fu Jiang and Shen Qi compounds, the DβH activity in serum, cortisone in adrenal gland and NE, DA amount in brain were increased, but serotonin was decreased, and after 7 days the effect was increased significantly. Both compounds could excite the sympathetic nerve and endocrine system in the peripheral and central nervous systems.Shen Qi compound acts quickly,but does not last as long as Fu Jiang.The effect will be better if the two compounds are used together.

关 键 词：虚寒证动物模型 神经递质 内分泌 

分 类 号：R254.05[医药卫生—中医内科学]