高脂蛋白血症与冠心病患者血清载脂蛋白CⅡ含量的变化  

Changes of serum apolipoprotein C Ⅱ level in patients with hyperlipoproteinemia and coronary heart disease

作　　者：黎健[1] 李红霞[1] 蒋雷[1] 

机构地区：[1]卫生部北京老年医学研究所

出　　处：《中华老年医学杂志》1997年第2期83-86,共4页Chinese Journal of Geriatrics

摘　　要：目的观察血清载脂蛋白ＣⅡ（ａｐｏＣⅡ）在高脂蛋白血症及冠心病中的变化特点。方法应用酶联免疫法（ＥＬＩＳＡ）测定新生儿至老年人群及１１８例高脂蛋白血症患者、４６例冠心病（ＣＨＤ）、５４例急性心肌梗死（ＡＭＩ）与２５例陈旧性心肌梗死（ＯＭＩ）患者血清ａｐｏＣⅡ含量，并分析与甘油三酯（ＴＧ）、高密度脂蛋白（ＨＤＬ）的关系。结果脐带血ａｐｏＣⅡ含量最低，随着年龄增长，ａｐｏＣⅡ含量逐渐增加。高脂蛋白血症组ａｐｏＣⅡ显著高于老年健康组（Ｐ＜０．００１），ａｐｏＣⅡ与ＴＧ含量呈正相关（ｒ＝０．５２，Ｐ＜０．００１），但有１０例患者ＴＧ很高，而ａｐｏＣⅡ较低。ＣＨＤ、ＡＭＩ和ＯＭＩ组的ａｐｏＣⅡ水平随着ＨＤＬ－Ｃ下降而显著低于老年健康组。结论血清ａｐｏＣⅡ的测定有助于阐明高脂蛋白血症的发病机理及ＣＨＤ、ＡＭＩ和ＯＭＩ患者的血脂紊乱、ａｐｏＣⅡ水平下降可能是某些病例ＴＧ升高的原因之一。Objective \ Variations of serum apolipoprotein(apo)C Ⅱ in the elderly and in patients with hyperlipoproteinemia and coronary heart disease(CHD) were studied.\ \ Methods\ Using ELISA,serum apo C Ⅱ levels were determined in Chinese subjects from neonates to elderlies,118 patients with hyperlipoproteinemia, 46 patients with CHD,54 patients with acute myocardial infarction(AMI) and 25 patients with old myocardial infarction(OMI). The association of apo C Ⅱ with serum triglycerides(TG) and high density lipoprotein level was observed.\ \ Results\ Apo C Ⅱ was at the lowest level in the cord blood but its level increased throughout the whole life span after birth. In comparision with the results in a control group,apo C Ⅱ levels were significantly decreased in CHD, AMI and OMI groups.Apo C Ⅱ level was remarkably increased in the hyperlipoproteinemic group( P <0 001)and correlatedpositively with TG( r =0 52, P <0 001). However,10 hypertriglyceridemic patients were found to have low apo C Ⅱ level. Conclusions It is suggested that apo C Ⅱ is a valuable serum marker for assessing the pathogenicity of hyperlipoproteinemia and lipid metabolic disorders.It is suggested that elevation of serum TG in some cases mightbe due to low apo C Ⅱ levels. \ \

关 键 词：高脂血症 血液 载脂蛋白C类 冠心病 

分 类 号：R589.202[医药卫生—内分泌] R541.402[医药卫生—内科学]