7.5%高渗氯化钠溶液复苏失血性休克对红细胞能量代谢的影响  

Effect of 7 5% hypertonic saline as a resuscitation solution for hemorrhagic shock on the energy metabolism of erythrocyte

作　　者：卢家凯[1] 刘怀琼[2] 汪志文[1] 潘贤佖[1] 

机构地区：[1]北京军区总医院麻醉科 [2]重庆市第三军医大学大坪医院麻醉科

出　　处：《中华麻醉学杂志》1997年第4期232-234,共3页Chinese Journal of Anesthesiology

摘　　要：目的：观察小剂量高渗氯化钠（ＨＳ）复苏失血性休克时红细胞（ＲＢＣ）能量代谢的变化。方法：２０只健康家兔被随机分为三组，（甲组）正常血容量输注ＨＳ组；（乙组）休克输注ＮＳ复苏组；（丙组）休克输注ＨＳ复苏组。以ＲＢＣ内ＡＴＰ和２，３－ＤＰＧ水平作为ＲＢＣ能量代谢的指标。结果：休克后ＲＢＣ内ＡＴＰ和２，３－ＤＰＧ水平显著下降，应用小剂量ＨＳ复苏后两项指标均有所回升，在输注后１２０分钟有显著增高。结论：应用小剂量ＨＳ可使失血性休克后的ＲＢＣ能量代谢状态发生明显改善，这可能是促进ＨＳ有效复苏休克的重要因素。Objective:To evaluate the effect of 7 5% hуpertonic saline (HS) on the energy matabolism of erythrocyte Method:Twenty adult rabbits were divided into three experimental groups randomly Hemorrhagic shock was induced by slow bleeding from femoral artery,with MAP being reduced to 5 3kPa and being kept at this level for one hour The animals with normovolemia (group A,n=5) were infused intravenously with HS 4ml/kg,and the others with hemorrhagic shock were resuscitated with NS 4ml/kg,(group B,n=6) or HS 4ml/kg (group C,n=9) Blood samples were taken before shock,immediately following shock and 10,30,60,and 120 min after the infusion of HS or NS,to measure the intracellular concentration of ATP and 2,3 DPG of erythrocyte MAP was monitored continuously Result:The levels of intracellular ATP and 2,3 DPG decreased after shock,and increased gradually with the infusion of HS,most significatly at 120th min following the infusion Conclusion:the metabolism energy of erythrocyte after hemorrhagic shock is improved with small volume HS infusion,and this may be helpful in resuscitating hemorrhagic shock

关 键 词：盐水 高渗 休克 失血性休克 红细胞 

分 类 号：R605.971[医药卫生—急诊医学]