Does ‘Immortal DNA strand＇ exist in ‘immortal＇ stem cells？  

作　　者：Linheng Li 

机构地区：[1]Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

出　　处：《Cell Research》2007年第10期834-835,共2页细胞研究（英文版）

摘　　要：Stem cells function to generate differentiated cells, and, at the same time, are maintained as ‘immortal＇ cells through self-renewal. Accumulated evidence indicates that adult stem cells may be the most common precursor for cancers in adult mammalian tissue , and this concept is gaining increasing support . Meanwhile, this also raises the question of how stem cells, which have a much longer lifespan compared to other progenitor and mature cells, can avoid accumulating mutations from DNA replication errors, thereby reducing the risk of tumorigenesis.

关 键 词：干细胞 DNA 成熟细胞 细胞突变 

分 类 号：Q2[生物学—细胞生物学] R392[医药卫生—免疫学]